Human pluripotent stem cell-derived cardiomyocytes for assessment of anticancer drug-induced cardiotoxicity
Cardiotoxicity is a major cause of high attrition rates among newly developed drugs.
Moreover, anti-cancer treatment-induced cardiotoxicity is one of the leading reasons of …
Moreover, anti-cancer treatment-induced cardiotoxicity is one of the leading reasons of …
Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer
Abstract Purpose of Review This review explores the cardiovascular toxicity associated with
cancer therapies, emphasizing the significance of the growing field of cardio-oncology. It …
cancer therapies, emphasizing the significance of the growing field of cardio-oncology. It …
Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs
X Wang, Q Jia, Y Yu, H Wang, H Guo, X Ma… - Acta Pharmacologica …, 2021 - nature.com
Aconitine (ACO), a main active ingredient of Aconitum, is well-known for its cardiotoxicity.
However, the mechanisms of toxic action of ACO remain unclear. In the current study, we …
However, the mechanisms of toxic action of ACO remain unclear. In the current study, we …
The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin [in vivo/in vitro, C57BL/6 mice, AC16 and hiPSC-CMs]
X Guan, W Li, Y Wang, Q Zhao, X Yu, J Jiang, W Bian… - Toxicology Letters, 2023 - Elsevier
Recombinant human endostatin (rh-endostatin) is an anti-angiogenic drug, which is used for
the treatment of advanced non-small-cell lung cancer (NSCLC) and other cancers. However …
the treatment of advanced non-small-cell lung cancer (NSCLC) and other cancers. However …
Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
T Wu, Y Chen, C Yang, M Lu, F Geng, J Guo… - Cardiovascular …, 2023 - Springer
A growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements
to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of …
to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of …
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches
Compounds from plants that are used in traditional medicine may have medicinal properties.
It is well known that plants belonging to the genus Aconitum are highly poisonous. Utilizing …
It is well known that plants belonging to the genus Aconitum are highly poisonous. Utilizing …
Downregulation of miR-146a contributes to cardiac dysfunction induced by the tyrosine kinase inhibitor sunitinib
L Shen, C Li, H Zhang, S Qiu, T Fu, Y Xu - Frontiers in Pharmacology, 2019 - frontiersin.org
The main adverse effect of tyrosine kinase inhibitors, such as sunitinib, is cardiac contractile
dysfunction; however, the molecular mechanisms of this effect remain largely obscure …
dysfunction; however, the molecular mechanisms of this effect remain largely obscure …
[HTML][HTML] FGF13 deficiency ameliorates calcium signaling abnormality in heart failure by regulating microtubule stability
R Zhao, Y Yan, Y Dong, X Wang, X Li, R Qiao… - Biochemical …, 2024 - Elsevier
Calcium signaling abnormality in cardiomyocytes, as a key mechanism, is closely
associated with develo** heart failure. Fibroblast growth factor 13 (FGF13) demonstrates …
associated with develo** heart failure. Fibroblast growth factor 13 (FGF13) demonstrates …
Phosphoproteomics reveals a novel mechanism underlying the proarrhythmic effects of nilotinib, vandetanib, and mobocertinib
W Wu, J Sun, J Zhang, H Zhao, S Qiu, C Li, C Shi, Y Xu - Toxicology, 2024 - Elsevier
The use of tyrosine kinase inhibitors (TKIs) has resulted in significant occurrence of
arrhythmias. However, the precise mechanism of the proarrhythmic effect is not fully …
arrhythmias. However, the precise mechanism of the proarrhythmic effect is not fully …
Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation
C Li, W Wu, J **ng, W Yan, J Zhang, J Sun… - Food and Chemical …, 2023 - Elsevier
Sunitinib (SNT)-induced cardiotoxicity is associated with abnormal calcium regulation
caused by phosphoinositide 3 kinase inhibition in the heart. Berberine (BBR) is a natural …
caused by phosphoinositide 3 kinase inhibition in the heart. Berberine (BBR) is a natural …