Background—Chagas disease remains a significant public health issue and a major cause
of morbidity and mortality in Latin America. Despite nearly 1 century of research, the …

Autoimmunity occurs when the immune system recognizes and attacks host tissue. In
addition to genetic factors, environmental triggers (in particular viruses, bacteria and other …

Background The role of trypanocidal therapy in patients with established Chagas'
cardiomyopathy is unproven. Methods We conducted a prospective, multicenter …

Myocarditis is defined as an inflammation of the cardiac muscle. In humans, various
infectious and non-infectious triggers induce myocarditis with a broad spectrum of …

Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune
disease, as well as a probe useful in uncovering its etiologic agents. The hypothesis is …

The protozoan parasite Trypanosoma cruzi infects up to 20 million people in Latin America,
and the resulting disease (Chagas' disease) is a leading cause of heart disease and death …

Chagas disease is a debilitating human illness caused by infection with the protozoan
Trypanosoma cruzi. A capacity to invade and replicate within many different cell types is a …

The efficacy of treatment with nifurtimox and/or benznidazole among adults with chronic
Chagas disease with no previous electrocardiographic disturbances was evaluated over a …

One-third of all Trypanosoma cruzi-infected patients eventually develop chronic Chagas'
disease cardiomyopathy (CCC), a particularly lethal inflammatory dilated cardiomyopathy …

Parasitic infections previously seen only in develo** tropical settings can be currently
diagnosed worldwide due to travel and population migration. Some parasites may directly or …