Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

There is an urgent need to derive quantitative measures based on coherent neurobiological
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Background The left dorsolateral prefrontal cortex is a prime target for repetitive transcranial
magnetic stimulation (TMS) to treat neuropsychiatric disorders; thus, abundant efficacy data …

Importance Cognitive deficits in depression have been associated with poor functional
capacity, frontal neural circuit dysfunction, and worse response to conventional …

The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has
persisted among clinicians and the general public alike despite insufficient supporting …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

The development of neuroimaging methodologies to map brain connectivity has transformed
our understanding of psychiatric disorders, the distributed effects of brain stimulation, and …

Psychiatric illnesses are heterogeneous in nature. No illness manifests in the same way
across individuals, and no two patients with a shared diagnosis exhibit identical symptom …