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[HTML][HTML] Metabolic syndrome: updates on pathophysiology and management in 2021
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …
The genetics of obesity: from discovery to biology
The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …
[HTML][HTML] Causes of obesity: a review
B Masood, M Moorthy - Clinical Medicine, 2023 - Elsevier
Obesity research is advancing swiftly, but the increase in obesity prevalence is faster. Over
the past three decades, researchers have found that biopsychosocial factors determine …
the past three decades, researchers have found that biopsychosocial factors determine …
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …
Body adiposity is highly heritable, and human genetic studies can lead to biological and …
[HTML][HTML] Polygenic prediction of weight and obesity trajectories from birth to adulthood
Severe obesity is a rapidly growing global health threat. Although often attributed to
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …
[HTML][HTML] New advances in adaptive thermogenesis: UCP1 and beyond
Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …
The multifunctional role of herbal products in the management of diabetes and obesity: a comprehensive review
Obesity and diabetes are the most demanding health problems today, and their prevalence,
as well as comorbidities, is on the rise all over the world. As time goes on, both are …
as well as comorbidities, is on the rise all over the world. As time goes on, both are …
[HTML][HTML] Genetic and diet-induced animal models for non-alcoholic fatty liver disease (NAFLD) research
A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …
[HTML][HTML] Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity—The case of BBS obesity
A Horwitz, R Birk - Nutrients, 2023 - mdpi.com
Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …
[HTML][HTML] The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …
illuminated the central role of the brain leptin-melanocortin pathway in the control of …