Small-molecule fluorogenic probes for mitochondrial nanoscale imaging
Mitochondria are inextricably linked to the development of diseases and cell metabolism
disorders. Super-resolution imaging (SRI) is crucial in enhancing our understanding of …
disorders. Super-resolution imaging (SRI) is crucial in enhancing our understanding of …
Mechanisms of replication and repair in mitochondrial DNA deletion formation
GA Fontana, HL Gahlon - Nucleic acids research, 2020 - academic.oup.com
Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies
including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases …
including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases …
Clinical implementation of RNA sequencing for Mendelian disease diagnostics
Background Lack of functional evidence hampers variant interpretation, leaving a large
proportion of individuals with a suspected Mendelian disorder without genetic diagnosis …
proportion of individuals with a suspected Mendelian disorder without genetic diagnosis …
Regulation of mammalian mitochondrial dynamics: opportunities and challenges
Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
The impact of HIV-and ART-induced mitochondrial dysfunction in cellular senescence and aging
According to the WHO, 38 million individuals were living with human immunodeficiency virus
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …
(HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019 …
Mitochondrial energy generation disorders: genes, mechanisms, and clues to pathology
Inherited disorders of oxidative phosphorylation cause the clinically and genetically
heterogeneous diseases known as mitochondrial energy generation disorders, or …
heterogeneous diseases known as mitochondrial energy generation disorders, or …
Therapies for mitochondrial diseases and current clinical trials
Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders
that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular …
that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular …
Metabolism and innate immunity meet at the mitochondria
Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …
Mitochondrial fission and fusion: molecular mechanisms, biological functions, and related disorders
Mitochondria are dynamic organelles that undergo fusion and fission. These active
processes occur continuously and simultaneously and are mediated by nuclear-DNA …
processes occur continuously and simultaneously and are mediated by nuclear-DNA …
Mitochondrial dynamics: Biological roles, molecular machinery, and related diseases
Mitochondria are dynamic organelles that undergo fusion, fission, movement, and
mitophagy. These processes are essential to maintain the normal mitochondrial …
mitophagy. These processes are essential to maintain the normal mitochondrial …