Conventional antidepressants are widely employed in several psychiatric and neurologic
disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are …

Exposures to stress at all stages of development can lead to long-term behavioural effects,
in part through changes in the epigenome. This review describes rodent research …

Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated
with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have …

Studies in rodents and captive primates suggest that the early-life social environment affects
future phenotype, potentially through alterations to DNA methylation. Little is known of these …

Early life adversity (ELA) increases risk for negative health outcomes, with sex disparities in
prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA …

Objective To determine the influence of maternal trauma and posttraumatic stress disorder
(PTSD) symptoms on children's physiological response to threat and safety signals during a …

Importance The labor migration of parents in China often leaves children behind, which may
be adversely associated with children's health. However, few studies have assessed the …

Early-life adversity caused by poor social bonding and deprived maternal care is known to
affect mental wellbeing and physical health. It is a form of chronic social stress that persists …

The early life environment markedly influences brain and behavioral development, with
adverse experiences associated with increased risk of anxiety and depressive phenotypes …

Lifelong indices of maladaptive behavior or illness often stem from early physiological
aberrations during periods of dynamic development. This is especially true when …