Innate immune response to Salmonella typhimurium, a model enteric pathogen

P Broz, MB Ohlson, DM Monack - Gut microbes, 2012 - Taylor & Francis
The innate immune system provides the first line of defense against invading
microorganisms by inducing a variety of inflammatory and antimicrobial responses. These …

Host specificity of bacterial pathogens

A Bäumler, FC Fang - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Most pathogens are able to infect multiple hosts but some are highly adapted to a single-
host species. A detailed understanding of the basis of host specificity can provide important …

Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

M Raffatellu, RL Santos, DE Verhoeven, MD George… - Nature medicine, 2008 - nature.com
Salmonella typhimurium causes a localized enteric infection in immunocompetent
individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here …

Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine

M Raffatellu, MD George, Y Akiyama, MJ Hornsby… - Cell host & …, 2009 - cell.com
In response to enteric pathogens, the inflamed intestine produces antimicrobial proteins, a
process mediated by the cytokines IL-17 and IL-22. Salmonella enterica serotype …

Now you see me, now you don't: the interaction of Salmonella with innate immune receptors

AM Keestra-Gounder, RM Tsolis… - Nature Reviews …, 2015 - nature.com
Salmonella enterica serovars are associated with an estimated 1 million deaths annually
and are also useful model organisms for investigating the mechanisms of host–bacterium …

Life in the inflamed intestine, Salmonella style

RL Santos, M Raffatellu, CL Bevins, LG Adams… - Trends in …, 2009 - cell.com
The lower gastrointestinal tract is densely populated with resident microbial communities
(microbiota), which do not elicit overt host responses but rather provide benefit to the host …

Salmonella enterica serovar Typhi and gallbladder cancer: a case–control study and meta‐analysis

J Koshiol, A Wozniak, P Cook, C Adaniel… - Cancer …, 2016 - Wiley Online Library
In Chile, where gallbladder cancer (GBC) rates are high and typhoid fever was endemic until
the 1990s, we evaluated the association between Salmonella enterica serovar Typhi (S …

The Pyromaniac Inside You: Salmonella Metabolism in the Host Gut

F Rivera-Chávez, AJ Bäumler - Annual review of microbiology, 2015 - annualreviews.org
A metabolically diverse microbial community occupies all available nutrient-niches in the
lumen of the mammalian intestine, making it difficult for pathogens to establish themselves in …

Comparative Analysis of Salmonella Genomes Identifies a Metabolic Network for Escalating Growth in the Inflamed Gut

SP Nuccio, AJ Bäumler - MBio, 2014 - Am Soc Microbiol
The Salmonella genus comprises a group of pathogens associated with illnesses ranging
from gastroenteritis to typhoid fever. We performed an in silico analysis of comparatively …

The inflammatory inception of gallbladder cancer

JA Espinoza, C Bizama, P García, C Ferreccio… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Gallbladder cancer is a lethal disease with notable geographical variations worldwide and a
predilection towards women. Its main risk factor is prolonged exposure to gallstones …