Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Induced pluripotent stem cell technology: a decade of progress
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …
enormous progress has been made in stem cell biology and regenerative medicine. Human …
Survivin at a glance
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …
Genomic instability of iPSCs: challenges towards their clinical applications
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …
from mature cells through the introduction of key transcription factors. iPSCs can be …
The potential and limitations of induced pluripotent stem cells to achieve wound healing
Wound healing is the physiologic response to a disruption in normal skin architecture and
requires both spatial and temporal coordination of multiple cell types and cytokines. This …
requires both spatial and temporal coordination of multiple cell types and cytokines. This …
Human autologous iPSC–derived dopaminergic progenitors restore motor function in Parkinson's disease models
Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal
dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the …
dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the …
Combinatorial therapies after spinal cord injury: how can biomaterials help?
Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function
below the injury site and is associated with a poor prognosis. The inhibitory environment that …
below the injury site and is associated with a poor prognosis. The inhibitory environment that …
Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord …
Transplantation of pluripotent stem cells and their differentiated progeny has the potential to
preserve or regenerate functional pathways and improve function after central nervous …
preserve or regenerate functional pathways and improve function after central nervous …
Past, present, and future of cell replacement therapy for parkinson's disease: a novel emphasis on host immune responses
Parkinson's disease (PD) stands as the second most common neurodegenerative disorder
after Alzheimer's disease, and its prevalence continues to rise with the aging global …
after Alzheimer's disease, and its prevalence continues to rise with the aging global …
Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-
derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived …
derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived …