Oxadiazole scaffold is one of the most important heterocyclic fragments, which is considered
as a perspective building block for drug discovery. Substituted 1, 3, 4-oxadiazoles had been …

Background Acute lung injury (ALI) together with acute respiratory distress syndrome
(ARDS) are associated with high rate of mortality and morbidity in patients. In the current …

Fluorouracil (5-FU) is one of the most commonly prescribed anti-cancer agent. However, its
use is associated with several debilitating adverse effects such as intestinal mucositis (IM) …

Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent
seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) …

Plants are regarded as a valuable and inexpensive source of new drug development, and a
variety of plant compounds are now being used in clinical trials to treat a variety of ailments …

Ethnopharmacological relevance Traditional plant-derived medicines have enabled the
mankind in curing the wide spectrum of diseases throughout the ages. Andrographis …

Fluorouracil (5-FU)-induced intestinal mucositis (IM) is one of the most common oncological
problem. It involves serious clinical consequences such as diarrhea, erythematous lesions …

In the current study, the N-benzylidene-4-((2-hydroxynaphthalene-1-yl) diazenyl) hydrazides
(NCHDH and NTHDH) were evaluated against the Carrageenan-and CFA-induced models …

Pentazocine (PTZ), a narcotic-antagonist analgesic, has been extensively used in the
treatment of initial carcinogenic or postoperative pain. Hepatic first-pass metabolism results …

The 25‐methoxy hispidol A (25‐MHA) is a triterpenoid, isolated from the immature fruit of
Poncirus trifoliata (Rutaceae). The pretreatment with 25‐MHA markedly (p< 0.001) …