Therapeutic mechanisms of glucocorticoids
Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …
Targeting the transferrin receptor for brain drug delivery
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …
development of therapeutics to treat diseases of the central nervous system. The main …
Nanotechnology: a promising approach for delivery of neuroprotective drugs
Central nervous system (CNS) disorders especially neurodegenerative disorders are the
major challenge for public health and demand the great attention of researchers to protect …
major challenge for public health and demand the great attention of researchers to protect …
Macrophages in heterotopic ossification: from mechanisms to therapy
Y Huang, X Wang, D Zhou, W Zhou, F Dai… - NPJ Regenerative …, 2021 - nature.com
Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …
Nanotechnology: intelligent design to treat complex disease
The purpose of this expert review is to discuss the impact of nanotechnology in the treatment
of the major health threats including cancer, infections, metabolic diseases, autoimmune …
of the major health threats including cancer, infections, metabolic diseases, autoimmune …
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis …
In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …
specimens, different approaches must be undertaken to better understand disease …
Nanoparticles in modern medicine: state of the art and future challenges
SK Murthy - International journal of nanomedicine, 2007 - Taylor & Francis
Nanoparticles are materials with overall dimensions in the nanoscale, ie, under 100 nm. In
recent years, these materials have emerged as important players in modern medicine, with …
recent years, these materials have emerged as important players in modern medicine, with …
Genomic and nongenomic effects of glucocorticoids
C Stahn, F Buttgereit - Nature clinical practice Rheumatology, 2008 - nature.com
The strong anti-inflammatory and immunosuppressive effects of glucocorticoids are
mediated primarily by the cytosolic glucocorticoid receptors. These receptors are members …
mediated primarily by the cytosolic glucocorticoid receptors. These receptors are members …
Nanoscale drug delivery systems and the blood–brain barrier
The protective properties of the blood–brain barrier (BBB) are conferred by the intricate
architecture of its endothelium coupled with multiple specific transport systems expressed on …
architecture of its endothelium coupled with multiple specific transport systems expressed on …
Getting into the brain: approaches to enhance brain drug delivery
Being the most delicate organ of the body, the brain is protected against potentially toxic
substances by the blood-brain barrier (BBB), which restricts the entry of most …
substances by the blood-brain barrier (BBB), which restricts the entry of most …