Background: A sensitive and acceptable screening regimen for women at high risk for breast
cancer is essential. Contrast-enhanced magnetic resonance imaging (MRI) of the breast is …

Ovarian cancer is characterize by few early symptoms, presentation at an advanced stage,
and poor survival. As a result, it is the most frequent cause of death from gynecological …

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with
inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 …

Background The value of regular surveillance for breast cancer in women with a genetic or
familial predisposition to breast cancer is currently unproven. We compared the efficacy of …

Purpose To compare the effectiveness of mammography, breast ultrasound, and magnetic
resonance imaging (MRI) for surveillance of women at increased familial risk for breast …

Background Risk-reducing sal**o-oophorectomy is often considered by carriers of BRCA
mutations who have completed childbearing. However, there are limited data supporting the …

ContextCurrent recommendations for women who have a BRCA1 or BRCA2 mutation are to
undergo breast surveillance from age 25 years onward with mammography annually and …

Abstract In 2003, the American Cancer Society updated its guidelines for early detection of
breast cancer based on recommendations from a formal review of evidence and a recent …

Purpose In the United States, 3.8 million women have a history of breast (BC) or ovarian
cancer (OC). Up to 15% of cases are attributable to heritable mutations, which, if identified …

ContextGenetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to
the care of women with a severe family history of breast or ovarian cancer, but an unknown …