The promise of combination therapies with FOXM1 inhibitors for cancer treatment

N Merjaneh, M Hajjar, YW Lan, VV Kalinichenko… - Cancers, 2024 - mdpi.com
Simple Summary FOXM1 is an oncogenic transcription factor that has been implicated in
cancer progression, metastases, and chemotherapy resistance. Multiple small-molecule …

Patient-specific data fusion defines prognostic cancer subtypes

Y Yuan, RS Savage, F Markowetz - PLoS computational biology, 2011 - journals.plos.org
Different data types can offer complementary perspectives on the same biological
phenomenon. In cancer studies, for example, data on copy number alterations indicate …

RNA and DNA microarrays

SC Sealfon, TT Chu - Biological Microarrays: Methods and Protocols, 2011 - Springer
The development of microarray technology has revolutionized RNA and deoxyribonucleic
acid (DNA) research. In contrast with traditional biological assays, microarrays allow the …

FOXM1 promotes malignant biological behavior and metabolic reprogramming by targeting SPINK1 in hepatocellular carcinoma and affecting the p53 pathway

X Ding, J Shi, Z Lei, G Wang, C Fu, X Su… - Biochimica et Biophysica …, 2025 - Elsevier
This study investigates the role of SPINK1 in liver cancer and its regulatory relationship with
FOXM1. Using differential gene analysis in the GEO database, SPINK1 was identified as …

Copy number and gene expression differences between African American and Caucasian American prostate cancer

AE Rose, JM Satagopan, C Oddoux, Q Zhou… - Journal of translational …, 2010 - Springer
Background The goal of our study was to investigate the molecular underpinnings
associated with the relatively aggressive clinical behavior of prostate cancer (PCa) in African …

Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer

M Kluth, R Ahrary, C Hube-Magg, M Ahmed… - …, 2015 - pmc.ncbi.nlm.nih.gov
Deletion of 12p is a recurrent alteration in prostate cancer, but the prevalence and clinical
consequences of this alteration have not been studied in detail. Dual labeling fluorescence …

Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation

XS Ke, Y Qu, N Goldfinger, K Rostad, R Hovland… - PloS one, 2008 - journals.plos.org
Background Epithelial to mesenchymal transition (EMT) has been connected with cancer
progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has …

Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines

NV Marella, KS Malyavantham, J Wang, S Matsui… - Cancer …, 2009 - aacrjournals.org
We used a combination of spectral karyoty**, array comparative genomic hybridization,
and cDNA microarrays to gain insights into the structural and functional changes of the …

Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men

J Beuten, JAL Gelfond, ML Martinez-Fierro… - …, 2009 - academic.oup.com
Genoty** of a 615 kb region within 8q24 with 49 haplotype-tagged single-nucleotide
polymorphisms (SNPs) in 2109 samples (797 cases and 1312 controls) of two ethnic/racial …

Establishment of a genomic-clinicopathologic nomogram for predicting early recurrence of hepatocellular carcinoma after R0 resection

B Yu, H Liang, Q Ye, Y Wang - Journal of Gastrointestinal Surgery, 2021 - Elsevier
Background A high rate of postoperative recurrence, especially early recurrence (ER)
occurring within 1 year, seriously impedes patients with hepatocellular carcinoma (HCC) …