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The promise of combination therapies with FOXM1 inhibitors for cancer treatment
Simple Summary FOXM1 is an oncogenic transcription factor that has been implicated in
cancer progression, metastases, and chemotherapy resistance. Multiple small-molecule …
cancer progression, metastases, and chemotherapy resistance. Multiple small-molecule …
Patient-specific data fusion defines prognostic cancer subtypes
Different data types can offer complementary perspectives on the same biological
phenomenon. In cancer studies, for example, data on copy number alterations indicate …
phenomenon. In cancer studies, for example, data on copy number alterations indicate …
RNA and DNA microarrays
SC Sealfon, TT Chu - Biological Microarrays: Methods and Protocols, 2011 - Springer
The development of microarray technology has revolutionized RNA and deoxyribonucleic
acid (DNA) research. In contrast with traditional biological assays, microarrays allow the …
acid (DNA) research. In contrast with traditional biological assays, microarrays allow the …
FOXM1 promotes malignant biological behavior and metabolic reprogramming by targeting SPINK1 in hepatocellular carcinoma and affecting the p53 pathway
X Ding, J Shi, Z Lei, G Wang, C Fu, X Su… - Biochimica et Biophysica …, 2025 - Elsevier
This study investigates the role of SPINK1 in liver cancer and its regulatory relationship with
FOXM1. Using differential gene analysis in the GEO database, SPINK1 was identified as …
FOXM1. Using differential gene analysis in the GEO database, SPINK1 was identified as …
Copy number and gene expression differences between African American and Caucasian American prostate cancer
AE Rose, JM Satagopan, C Oddoux, Q Zhou… - Journal of translational …, 2010 - Springer
Background The goal of our study was to investigate the molecular underpinnings
associated with the relatively aggressive clinical behavior of prostate cancer (PCa) in African …
associated with the relatively aggressive clinical behavior of prostate cancer (PCa) in African …
Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer
M Kluth, R Ahrary, C Hube-Magg, M Ahmed… - …, 2015 - pmc.ncbi.nlm.nih.gov
Deletion of 12p is a recurrent alteration in prostate cancer, but the prevalence and clinical
consequences of this alteration have not been studied in detail. Dual labeling fluorescence …
consequences of this alteration have not been studied in detail. Dual labeling fluorescence …
Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation
XS Ke, Y Qu, N Goldfinger, K Rostad, R Hovland… - PloS one, 2008 - journals.plos.org
Background Epithelial to mesenchymal transition (EMT) has been connected with cancer
progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has …
progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has …
Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines
We used a combination of spectral karyoty**, array comparative genomic hybridization,
and cDNA microarrays to gain insights into the structural and functional changes of the …
and cDNA microarrays to gain insights into the structural and functional changes of the …
Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men
Genoty** of a 615 kb region within 8q24 with 49 haplotype-tagged single-nucleotide
polymorphisms (SNPs) in 2109 samples (797 cases and 1312 controls) of two ethnic/racial …
polymorphisms (SNPs) in 2109 samples (797 cases and 1312 controls) of two ethnic/racial …
Establishment of a genomic-clinicopathologic nomogram for predicting early recurrence of hepatocellular carcinoma after R0 resection
B Yu, H Liang, Q Ye, Y Wang - Journal of Gastrointestinal Surgery, 2021 - Elsevier
Background A high rate of postoperative recurrence, especially early recurrence (ER)
occurring within 1 year, seriously impedes patients with hepatocellular carcinoma (HCC) …
occurring within 1 year, seriously impedes patients with hepatocellular carcinoma (HCC) …