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Antimicrobial peptides targeting gram-positive bacteria
N Malanovic, K Lohner - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …
Role of lipids in the interaction of antimicrobial peptides with membranes
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …
defense against pathogens. Recurrent structural and functional aspects are observed …
The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
A De Breij, M Riool, RA Cordfunke… - Science translational …, 2018 - science.org
Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …
Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions
MH Chiu, EJ Prenner - Journal of Pharmacy and Bioallied …, 2011 - journals.lww.com
Abstract Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the
thermotropic properties of many different biological macromolecules and extracts. Since its …
thermotropic properties of many different biological macromolecules and extracts. Since its …
Antifungal peptides: To be or not to be membrane active
Most antifungal peptides (AFPs), if not all, have membrane activity, while some also have
alternative targets. Fungal membranes share many characteristics with mammalian …
alternative targets. Fungal membranes share many characteristics with mammalian …
[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
Antimicrobial peptides: promising compounds against pathogenic microorganisms
In the last decades, the indiscriminate use of conventional antibiotics has generated high
rates of microbial resistance. This situation has increased the need for obtaining new …
rates of microbial resistance. This situation has increased the need for obtaining new …
New strategies for novel antibiotics: peptides targeting bacterial cell membranes.
K Lohner - General physiology and biophysics, 2009 - europepmc.org
Membranes are targets of host defence or antimicrobial peptides, effector molecules of
innate immunity that evolved in nature to contend with invaders as an active system of …
innate immunity that evolved in nature to contend with invaders as an active system of …
[HTML][HTML] The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes
D Koller, K Lohner - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
Research on antimicrobial peptides is in part driven by urgent medical needs such as the
steady increase in pathogens being resistant to antibiotics. Despite the wealth of information …
steady increase in pathogens being resistant to antibiotics. Despite the wealth of information …
The chemistry and biology of LL-37
MF Burton, PG Steel - Natural product reports, 2009 - pubs.rsc.org
Covering: up to June 2009LL-37 is a human host defence peptide that has a wide range of
biological functions, including antimicrobial and immunomodulatory properties. This review …
biological functions, including antimicrobial and immunomodulatory properties. This review …