Antimicrobial peptides targeting gram-positive bacteria

N Malanovic, K Lohner - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …

Role of lipids in the interaction of antimicrobial peptides with membranes

V Teixeira, MJ Feio, M Bastos - Progress in lipid research, 2012 - Elsevier
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

A De Breij, M Riool, RA Cordfunke… - Science translational …, 2018 - science.org
Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …

Differential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions

MH Chiu, EJ Prenner - Journal of Pharmacy and Bioallied …, 2011 - journals.lww.com
Abstract Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the
thermotropic properties of many different biological macromolecules and extracts. Since its …

Antifungal peptides: To be or not to be membrane active

M Rautenbach, AM Troskie, JA Vosloo - Biochimie, 2016 - Elsevier
Most antifungal peptides (AFPs), if not all, have membrane activity, while some also have
alternative targets. Fungal membranes share many characteristics with mammalian …

[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

G Wang, B Mishra, RF Epand, RM Epand - Biochimica et Biophysica Acta …, 2014 - Elsevier
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …

Antimicrobial peptides: promising compounds against pathogenic microorganisms

J Cruz, C Ortiz, F Guzman… - Current medicinal …, 2014 - benthamdirect.com
In the last decades, the indiscriminate use of conventional antibiotics has generated high
rates of microbial resistance. This situation has increased the need for obtaining new …

New strategies for novel antibiotics: peptides targeting bacterial cell membranes.

K Lohner - General physiology and biophysics, 2009 - europepmc.org
Membranes are targets of host defence or antimicrobial peptides, effector molecules of
innate immunity that evolved in nature to contend with invaders as an active system of …

[HTML][HTML] The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes

D Koller, K Lohner - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
Research on antimicrobial peptides is in part driven by urgent medical needs such as the
steady increase in pathogens being resistant to antibiotics. Despite the wealth of information …

The chemistry and biology of LL-37

MF Burton, PG Steel - Natural product reports, 2009 - pubs.rsc.org
Covering: up to June 2009LL-37 is a human host defence peptide that has a wide range of
biological functions, including antimicrobial and immunomodulatory properties. This review …