TGF-β Signaling
K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
Mechanisms of TGF-β signaling from cell membrane to the nucleus
TGF-β signaling controls a plethora of cellular responses and figures prominently in animal
development. Recent cellular, biochemical, and structural studies have revealed significant …
development. Recent cellular, biochemical, and structural studies have revealed significant …
TGF-β signalling from cell membrane to nucleus through SMAD proteins
CH Heldin, K Miyazono, P Ten Dijke - Nature, 1997 - nature.com
The recent identification of the SMAD family of signal transducer proteins has unravelled the
mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane …
mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane …
Targeting TGFβ signal transduction for cancer therapy
S Liu, J Ren, P Ten Dijke - Signal transduction and targeted therapy, 2021 - nature.com
Transforming growth factor-β (TGFβ) family members are structurally and functionally related
cytokines that have diverse effects on the regulation of cell fate during embryonic …
cytokines that have diverse effects on the regulation of cell fate during embryonic …
TGF-β signaling from receptors to Smads
A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …
Signaling receptors for TGF-β family members
CH Heldin, A Moustakas - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …
of type I and type II dual specificity kinase receptors. The activation and stability of the …
[HTML][HTML] Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
Smad proteins play a key role in the intracellular signalling of transforming growth factor β
(TGFβ), which elicits a large variety of cellular responses. Upon TGFβ receptor activation …
(TGFβ), which elicits a large variety of cellular responses. Upon TGFβ receptor activation …
Smad regulation in TGF-β signal transduction
A Moustakas, S Souchelnytskyi… - Journal of cell …, 2001 - journals.biologists.com
Smad proteins transduce signals from transforming growth factor-β (TGF-β) superfamily
ligands that regulate cell proliferation, differentiation and death through activation of receptor …
ligands that regulate cell proliferation, differentiation and death through activation of receptor …
Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
L Gorelik, RA Flavell - Immunity, 2000 - cell.com
Targeted mutation of TGFβ1 in mice demonstrated that TGFβ1 is one of the key negative
regulators of immune homeostasis, as its absence leads to activation of a self-targeted …
regulators of immune homeostasis, as its absence leads to activation of a self-targeted …
[HTML][HTML] SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
T Tsukazaki, TA Chiang, AF Davison, L Attisano… - Cell, 1998 - cell.com
Smads transmit signals from transmembrane ser/thr kinase receptors to the nucleus. We
now identify SARA (for S mad a nchor for r eceptor a ctivation), a FYVE domain protein that …
now identify SARA (for S mad a nchor for r eceptor a ctivation), a FYVE domain protein that …