Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to
germinal niches functions as neural stem cells (NSCs) that produce various types of …

Many forms of blindness result from the dysfunction or loss of retinal photoreceptors.
Induced pluripotent stem cells (iPSCs) hold great potential for the modelling of these …

Lineage studies conducted in the retina more than 25 years ago demonstrated the
multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by …

Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior develo** brain …

Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the develo** central nervous system. In …

In the develo** vertebrate retina, diverse neuronal subtypes originate from multipotent
progenitors in a conserved order and are integrated into an intricate laminated architecture …

The protein neural retina leucine zipper (Nrl) is a basic motif–leucine zipper transcription
factor that is preferentially expressed in rod photoreceptors,. It acts synergistically with Crx to …

Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …