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Sex differences in anxiety and depression: circuits and mechanisms
Epidemiological sex differences in anxiety disorders and major depression are well
characterized. Yet the circuits and mechanisms that contribute to these differences are …
characterized. Yet the circuits and mechanisms that contribute to these differences are …
The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research
Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …
disabling. Although exposure-based treatments are effective, a substantial number of …
Optimizing exposure therapy with an inhibitory retrieval approach and the OptEx Nexus
Research from recent decades has highlighted the distinction between excitatory and
inhibitory Pavlovian learning mechanisms. Based on this distinction, state-of-the-art …
inhibitory Pavlovian learning mechanisms. Based on this distinction, state-of-the-art …
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Posttraumatic stress disorder can be viewed as a disorder of fear dysregulation. An
abundance of research suggests that the prefrontal cortex is central to fear processing—that …
abundance of research suggests that the prefrontal cortex is central to fear processing—that …
Network mechanisms of clinical response to transcranial magnetic stimulation in posttraumatic stress disorder and major depressive disorder
Background Repetitive transcranial magnetic stimulation (TMS) therapy can modulate
pathological neural network functional connectivity in major depressive disorder (MDD) …
pathological neural network functional connectivity in major depressive disorder (MDD) …
How processing of sensory information from the internal and external worlds shape the perception and engagement with the world in the aftermath of trauma …
Post-traumatic stress disorder (PTSD) is triggered by an individual experiencing or
witnessing a traumatic event, often precipitating persistent flashbacks and severe anxiety …
witnessing a traumatic event, often precipitating persistent flashbacks and severe anxiety …
Single-prolonged stress: a review of two decades of progress in a rodent model of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric
condition. However, the biological mechanisms underlying this disease are still largely …
condition. However, the biological mechanisms underlying this disease are still largely …
[HTML][HTML] Targeting the endocannabinoid system in the treatment of posttraumatic stress disorder: A promising case of preclinical-clinical translation?
The endocannabinoid (eCB) system is one the most ubiquitous signaling systems of the
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments
One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …
for the treatment of psychiatric and neurologic disorders is inter-and intra-individual …
Glucocorticoids and hippocampal structure and function in PTSD
This review examines the putative link between glucocorticoid and hippocampal
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …