Arbidol (ARB) is a Russian-made small indole-derivative molecule, licensed in Russia and
China for prophylaxis and treatment of influenza and other respiratory viral infections. It also …

The broad-spectrum antiviral drug Arbidol shows efficacy against influenza viruses by
targeting the hemagglutinin (HA) fusion machinery. However, the structural basis of the …

Background High morbidity and mortality of influenza virus infection have made it become
one of the most lethal diseases threatening public health; the lack of drugs with strong …

Arbidol (ARB) is a synthetic antiviral originally developed to combat influenza viruses. ARB
is currently used clinically in several countries but not in North America. We have previously …

There are many emerging and re-emerging globally prevalent viruses for which there are no
licensed vaccines or antiviral medicines. Arbidol (ARB, umifenovir), used clinically for …

Homologous recombination between corresponding RNA segments of different influenza
viruses has not been observed, in contrast to the high frequency of recombination observed …

In spite of vaccination was recommended by the World Health Organization, the main
strategy of influenza is antiviral drugs treatment, one of which is umifenovir. Aim. The aim of …

Introduction: Seasonal influenza and pandemic outbreaks typically result in high mortality
and morbidity associated with severe economic burdens. Vaccines and anti-influenza drugs …

Influenza is a highly contagious respiratory viral infection responsible for up to 50,000
deaths per annum in the US alone. The need for new therapeutics with novel modes of …

Influenza virus infections are the main contagious respiratory disease with high levels of
morbidity and mortality worldwide. Antiviral drugs are indispensable for the prophylaxis and …