Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …

Age and intraocular pressure (IOP) are the two most important risk factors for the
development and progression of open-angle glaucoma. While IOP is commonly considered …

Background Glaucoma is a chronic degenerative disease for which inflammation is
considered to play a pivotal role in the pathogenesis and progression. In this study, we …

Purpose.: Glaucoma is characterized by retinal ganglion cell (RGC) death and frequently
associated with elevated IOP. How RGCs degenerate before death is little understood, so …

Nanocrystal-based drug delivery systems provide important tools for ocular formulation
development, especially when considering poorly soluble drugs. The objective of the study …

Axon degeneration can arise from metabolic stress, potentially a result of mitochondrial
dysfunction or lack of appropriate substrate input. In this study, we investigated whether the …

The purpose of this study was to improve a mouse model of chronic intraocular pressure
(IOP) elevation utilizing microbead injection in two strains of mice and to assess the effect of …

It has been proposed that cerebrospinal fluid (CSF) can enter and leave the retina and optic
nerve along perivascular spaces surrounding the central retinal vessels as part of an …

Glaucoma is a prevalent neurodegenerative disease that is characterized by progressive
visual field loss. It is the leading cause of irreversible blindness in the world. The main risk …

Glaucoma is a neurodegenerative disorder characterized by mitochondrial dysfunction and
an increase in oxidative damage, leading to retinal ganglion cell (RGC) death. The oxidative …