Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow

AN Baker, GW Hawker-Bond, PG Georgiou… - Chemical Society …, 2022 - pubs.rsc.org
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …

The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device

AN Baker, SJ Richards, CS Guy, TR Congdon… - ACS central …, 2020 - ACS Publications
There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2),
which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a …

Factors affecting the performance of HRP2-based malaria rapid diagnostic tests

X Martiáñez-Vendrell, M Skjefte, R Sikka… - Tropical Medicine and …, 2022 - mdpi.com
The recent COVID-19 pandemic has profoundly impacted global malaria elimination
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …

The economic burden of malaria on households and the health system in a high transmission district of Mozambique

S Alonso, CJ Chaccour, E Elobolobo, A Nacima… - Malaria journal, 2019 - Springer
Background Malaria remains a leading cause of morbidity and mortality in Mozambique.
Increased investments in malaria control have reduced the burden, but few studies have …

Automated sickle cell disease identification in human red blood cells using a lensless single random phase encoding biosensor and convolutional neural networks

PM Douglass, T O'Connor, B Javidi - Optics Express, 2022 - opg.optica.org
We present a compact, field portable, lensless, single random phase encoding biosensor for
automated classification between healthy and sickle cell disease human red blood cells …

Glycan-based flow-through device for the detection of SARS-CoV-2

AN Baker, SJ Richards, S Pandey, CS Guy… - ACS …, 2021 - ACS Publications
The COVID-19 pandemic, and future pandemics, require diagnostic tools to track disease
spread and guide the isolation of (a) symptomatic individuals. Lateral-flow diagnostics …

Impact of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions on malaria control worldwide: a systematic review and meta-analysis

I Molina-de la Fuente, A Pastor, Z Herrador, A Benito… - Malaria journal, 2021 - Springer
Background Deletion of pfhrp2 and/or pfhrp3 genes cause false negatives in malaria rapid
diagnostic test (RDT) and threating malaria control strategies. This systematic review aims to …

Malaria and the 'last'parasite: how can technology help?

NM Pham, W Karlen, HP Beck, E Delamarche - Malaria journal, 2018 - Springer
Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly
infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but …

Improving Accuracy of Malaria Diagnosis in Underserved Rural and Remote Endemic Areas of Sub‐Saharan Africa: A Call to Develop Multiplexing Rapid Diagnostic …

RO Makanjuola, AW Taylor-Robinson - Scientifica, 2020 - Wiley Online Library
Clinical infection with malaria, caused by parasites of the genus Plasmodium, is considered
a serious medical condition with the potential to become a life‐threatening emergency. This …

Lateral Flow Glyco‐Assays for the Rapid and Low‐Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance

AN Baker, AR Muguruza, SJ Richards… - Advanced …, 2022 - Wiley Online Library
Lateral flow immuno‐assays, such as the home pregnancy test, are rapid point‐of‐care
diagnostics that use antibody‐coated nanoparticles to bind antigens/analytes (eg, viruses …