[HTML][HTML] Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies

B Li, P Thebault, B Labat, G Ladam, V Alt… - Journal of Orthopaedic …, 2024 - Elsevier
Objective Fracture-related infection (FRI) remains a major concern in orthopaedic trauma.
Functionalizing implants with antibacterial coatings are a promising strategy in mitigating …

Exploring the application of Graphene Oxide-based nanomaterials in the repair of osteoporotic fractures

H Zhou, J Chen, X Zhang, JJ Chen, J Chen, S Jia… - Nanomaterials, 2024 - mdpi.com
Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of
bone tissues and microstructures and impair their healing ability. Conventional internal …

[HTML][HTML] Biodegradable Zn-2Cu-0.5 Zr alloy promotes the bone repair of senile osteoporotic fractures via the immune-modulation of macrophages

H Ji, G Shen, H Liu, Y Liu, J Qian, GJ Wan, E Luo - Bioactive Materials, 2024 - Elsevier
Delayed bone-healing of senile osteoporotic fractures remains a clinical challenge due to
the alterations caused by aging in bone and immune systems. The novel biomaterials that …

A multifunctional scaffold for bone infection treatment by delivery of microRNA therapeutics combined with antimicrobial nanoparticles

JM Sadowska, RN Power, KJ Genoud… - Advanced …, 2024 - Wiley Online Library
Treating bone infections and ensuring bone repair is one of the greatest global challenges
of modern orthopedics, made complex by antimicrobial resistance (AMR) risks due to long …

Synergistic combination of baicalein and rifampicin against Staphylococcus aureus biofilms

R Muniyasamy, I Manjubala - Frontiers in Microbiology, 2024 - frontiersin.org
Staphylococcus aureus, a Gram-positive bacterium, is a predominant pathogen associated
with various infections. The rapid emergence of antibiotic resistance has intensified the …

[HTML][HTML] Hydrogel delivery of DNase I and liposomal vancomycin to eradicate fracture-related methicillin-resistant staphylococcus aureus infection and support …

J Li, SSY Leung, YL Chung, SKH Chow, V Alt, M Rupp… - Acta Biomaterialia, 2023 - Elsevier
Fracture-related infection (FRI) is a devastating complication in orthopedic surgery. A recent
study showed that FRI causes more severe infection and further delays healing in …

Bioactive composite hydrogel with effects of robust promoting osteogenesis and immunomodulation for osteoporotic bone regeneration

B Sun, H Wang, B **ao, H Yan, H Wu, R Zhang… - Chemical Engineering …, 2023 - Elsevier
Osteoporotic bone defect is an intractable challenge in clinical practice, involving impaired
bone repair ability and abnormal immune response. Despite the development of various …

Preventing septic implant failures in osteoporotic hip fractures using antibiotic-loaded functionalized nanocement

A Nikhil, I Qayoom, A Das, A Kumar - Chemical Engineering Journal, 2024 - Elsevier
Osteoporosis is a prevalent skeletal disorder and the most common cause of debilitating hip
fractures, primarily affecting post-menopausal women and elderly people. Implants used to …

[HTML][HTML] Effects of aging on osteosynthesis at bone–implant interfaces

AK Pius, M Toya, Q Gao, ML Lee, YS Ergul, SKH Chow… - Biomolecules, 2023 - mdpi.com
Joint replacement is a common surgery and is predominantly utilized for treatment of
osteoarthritis in the aging population. The longevity of many of these implants depends on …

A population-based epidemiological and health economic analysis of fracture-related infection

AL Foster, J Warren, K Vallmuur… - The Bone & Joint …, 2024 - boneandjoint.org.uk
Aims The aim of this study was to perform the first population-based description of the
epidemiological and health economic burden of fracture-related infection (FRI). Methods …