Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

Introduction Neutrophil accumulation is a well-established feature of Alzheimer's disease
(AD) and has been linked to cognitive impairment by modulating disease-relevant …

Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires
transendothelial migration (TEM). TEM involves several well-studied sequential adhesive …

Neutrophil diapedesis is an immediate step following infections and injury and is driven by
complex interactions between leukocytes and various components of the blood vessel wall …

Crossing the vascular endothelium is a necessary stage for circulating cells aiming to reach
distant organs. Leukocyte passage through the endothelium, known as transmigration, is a …

Background The monocarboxylate transporter 8 (MCT8) plays a vital role in maintaining
brain thyroid hormone homeostasis. This transmembrane transporter is expressed at the …

The inner layer of blood vessels consists of endothelial cells, which form the physical barrier
between blood and tissue. This vascular barrier is tightly regulated and is defined by cell-cell …

Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease
characterized by the loss of motor neurons. Dysregulated peripheral immunity has been …

Migrating cells preferentially breach and integrate epithelial and endothelial monolayers at
multicellular vertices. These sites are amenable to forces produced by the migrating cell and …