Proteins are workhorses in the cell; they form stable and more often dynamic, transient
protein–protein interactions, assemblies, and networks and have an intimate interplay with …

Conspectus Proximity labeling can be defined as an enzymatic “in-cell” chemical reaction
that catalyzes the proximity-dependent modification of biomolecules in live cells. Since the …

Cellular processes rely on the intimate interplay of different molecules, including DNA, RNA,
proteins, and metabolites. Obtaining and integrating data on their abundance and dynamics …

Map** the proteomic landscape of mitochondria with spatiotemporal precision plays a
pivotal role in elucidating the delicate biological functions and complex relationship with …

Abiotic stresses are major environmental conditions that reduce plant growth, productivity
and quality. Protein-protein interaction (PPI) approaches can be used to screen stress …

MELAS (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes) is a
progressive neurodegenerative disease caused by pathogenic mitochondrial DNA variants …

Mass spectrometry (MS) analysis is often challenged by contaminations from detergents,
salts, and polymers that compromise data quality and can damage the chromatography and …

Purpose The aim of this study was to explore an effective 124I labeling strategy and improve
the signal-to-noise ratio when evaluating the expression of PD-L1 using an 124I-iodinated …

Different brain cell types play distinct roles in brain development and disease. Molecular
characterization of cell-specific mechanisms using cell type–specific approaches at the …

Post-translational modifications of cellular substrates by members of the ubiquitin (Ub) and
ubiquitin-like (UbL) family are crucial for regulating protein homeostasis in organisms. The …