The role of single-protein elasticity in mechanobiology

AEM Beedle, S Garcia-Manyes - Nature Reviews Materials, 2023 - nature.com
In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

The function and pathogenic mechanism of filamin A

J Zhou, X Kang, H An, Y Lv, X Liu - Gene, 2021 - Elsevier
Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

Structure and function of filamin C in the muscle Z-disc

Z Mao, F Nakamura - International journal of molecular sciences, 2020 - mdpi.com
Filamin C (FLNC) is one of three filamin proteins (Filamin A (FLNA), Filamin B (FLNB), and
FLNC) that cross-link actin filaments and interact with numerous binding partners. FLNC …

A‐to‐I RNA editing of Filamin A regulates cellular adhesion, migration and mechanical properties

M Jain, A Weber, K Maly, G Manjaly, J Deek… - The FEBS …, 2022 - Wiley Online Library
A‐to‐I RNA editing by ADARs is an abundant epitranscriptomic RNA‐modification in
metazoa. In mammals, Flna pre‐mRNA harbours a single conserved A‐to‐I RNA editing site …

[HTML][HTML] On the competition between interface energy and temperature in phase transition phenomena

L Bellino, G Florio, S Giordano, G Puglisi - Applications in Engineering …, 2020 - Elsevier
Phase nucleation and propagation phenomena can be characterized by a cooperative
behavior regulated by non local interactions between the multistable domains and with the …

Thermodynamics of small systems with conformational transitions: The case of two-state freely jointed chains with extensible units

M Benedito, S Giordano - The Journal of Chemical Physics, 2018 - pubs.aip.org
Several experimental methods are usually applied for stretching single molecules and
provide valuable insights about the static and dynamic responses induced by externally …

Isotensional and isometric force-extension response of chains with bistable units and Ising interactions

M Benedito, S Giordano - Physical Review E, 2018 - APS
The combination of bistability and cooperativity plays a crucial role in several biological and
artificial micro-and nanosystems. In particular, the exhaustive understanding of the …

Role of Filamin C in Muscle Cells

DV Goliusova, MY Sharikova, KA Lavrenteva… - Biochemistry …, 2024 - Springer
Filamin C (FLNC) is a member of a high-molecular weight protein family, which bind actin
filaments in the cytoskeleton of various cells. In human genome FLNC is encoded by the …

Encoding mechano-memories in actin networks

S Majumdar, LC Foucard, AJ Levine… - arxiv preprint arxiv …, 2017 - arxiv.org
Understanding the response of complex materials to external force is central to fields
ranging from materials science to biology. Here, we describe a novel type of mechanical …

[PDF][PDF] Applications in Engineering Science

L Bellino, G Florio, S Giordano, G Puglisi - giordanostefano.it
abstract Phase nucleation and propagation phenomena can be characterized by a
cooperative behavior regulated by non local interactions between the multistable domains …