Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
The Italian Society for Pediatric Nephrology (SINePe) consensus document on the management of nephrotic syndrome in children: Part I-Diagnosis and treatment of …
A Pasini, E Benetti, G Conti, L Ghio, M Lepore… - Italian journal of …, 2017 - Springer
This consensus document is aimed at providing an updated, multidisciplinary overview on
the diagnosis and treatment of pediatric nephrotic syndrome (NS) at first presentation. It is …
the diagnosis and treatment of pediatric nephrotic syndrome (NS) at first presentation. It is …
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …
Evaluation of daily low-dose prednisolone during upper respiratory tract infection to prevent relapse in children with relapsing steroid-sensitive nephrotic syndrome …
Importance In children with corticosteroid-sensitive nephrotic syndrome, many relapses are
triggered by upper respiratory tract infections. Four small studies found that administration of …
triggered by upper respiratory tract infections. Four small studies found that administration of …
The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome
TA Al-Aubodah, L Aoudjit, G Pascale… - Nature …, 2023 - nature.com
The efficacy of the B cell-targeting drug rituximab (RTX) in childhood idiopathic nephrotic
syndrome (INS) suggests that B cells may be implicated in disease pathogenesis. However …
syndrome (INS) suggests that B cells may be implicated in disease pathogenesis. However …
The role of the immune system in idiopathic nephrotic syndrome
A Hackl, SEDA Zed, P Diefenhardt, J Binz-Lotter… - Molecular and Cellular …, 2021 - Springer
Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and
hypoalbuminemia and usually responds well to steroids. However, relapses are frequent …
hypoalbuminemia and usually responds well to steroids. However, relapses are frequent …
Minimal change disease: a “two-hit” podocyte immune disorder?
M Shimada, C Araya, C Rivard, T Ishimoto… - Pediatric …, 2011 - Springer
Minimal change disease (MCD) is the most common nephrotic syndrome in children and is
commonly thought to be a T-cell disorder mediated by a circulating factor that alters …
commonly thought to be a T-cell disorder mediated by a circulating factor that alters …
Serum immunoglobulins and risk of infection: how low can you go?
DE Furst - Seminars in arthritis and rheumatism, 2009 - Elsevier
OBJECTIVES: To determine the relationship between the levels of serum immunoglobulin
(Ig) levels and risk of infection. The following 2 main questions are addressed:(1) At what …
(Ig) levels and risk of infection. The following 2 main questions are addressed:(1) At what …
Molecular mechanisms of proteinuria in minimal change disease
S Purohit, F Piani, FA Ordoñez… - Frontiers in …, 2021 - frontiersin.org
Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome
in childhood and represents about 15% cases in adults. It is characterized by massive …
in childhood and represents about 15% cases in adults. It is characterized by massive …
[HTML][HTML] Immunosuppressive burden and risk factors of infection in primary childhood nephrotic syndrome
K Alfakeekh, M Azar, B Al Sowailmi… - Journal of infection and …, 2019 - Elsevier
Introduction Patients with primary childhood nephrotic syndrome (PCNS) develop alterations
in their cellular and humoral immunity that predisposes them to the development of infection …
in their cellular and humoral immunity that predisposes them to the development of infection …