Spermatogenesis in humans and its affecting factors
FTL Neto, PV Bach, BB Najari, PS Li… - Seminars in cell & …, 2016 - Elsevier
Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …
into spermatozoa requires the participation of several cell types, hormones, paracrine …
Genetics of the human Y chromosome and its association with male infertility
The human Y chromosome harbors genes that are responsible for testis development and
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …
[HTML][HTML] Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis
Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …
information to the next generation. Although extensively studied in mice, our current …
Human Y-chromosome variation in the genome-sequencing era
MA Jobling, C Tyler-Smith - Nature Reviews Genetics, 2017 - nature.com
The properties of the human Y chromosome–namely, male specificity, haploidy and escape
from crossing over—make it an unusual component of the genome, and have led to its …
from crossing over—make it an unusual component of the genome, and have led to its …
Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells
Establishment of spermatogonia throughout the fetal and postnatal period is essential for
production of spermatozoa and male fertility. Here, we establish a protocol for in vitro …
production of spermatozoa and male fertility. Here, we establish a protocol for in vitro …
Thoughts on the popularity of ICSI
M Haddad, J Stewart, P **e, S Cheung, A Trout… - Journal of assisted …, 2021 - Springer
Purpose Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted
reproductive technique (ART) worldwide. In this feature, we review the early assisted …
reproductive technique (ART) worldwide. In this feature, we review the early assisted …
Spermatogenic failure and the Y chromosome
C Krausz, E Casamonti - Human genetics, 2017 - Springer
The Y chromosome harbors a number of genes essential for testis development and
function. Its highly repetitive structure predisposes this chromosome to deletion/duplication …
function. Its highly repetitive structure predisposes this chromosome to deletion/duplication …
Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies
KTD Tran, H Valli-Pulaski, A Colvin… - Biology of …, 2022 - academic.oup.com
Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility
is an insidious disease that impacts not only the ability to have a biological child but also the …
is an insidious disease that impacts not only the ability to have a biological child but also the …
[HTML][HTML] Experimental methods to preserve male fertility and treat male factor infertility
Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …
families, and society, which extend far beyond the inability to have a biological child …
DDX3X and DDX3Y are redundant in protein synthesis
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X-and
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …