[HTML][HTML] Proteogenomic characterization of pancreatic ductal adenocarcinoma

L Cao, C Huang, DC Zhou, Y Hu, TM Lih, SR Savage… - Cell, 2021 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

Screening for pancreatic cancer has the potential to save lives, but is it practical?

BL Mazer, JW Lee, NJ Roberts, LC Chu… - Expert review of …, 2023 - Taylor & Francis
Introduction Most patients with pancreatic cancer present with advanced stage, incurable
disease. However, patients with high-grade precancerous lesions and many patients with …

A critical review of datasets and computational suites for improving cancer theranostics and biomarker discovery

G Ashok, S Ramaiah - Medical Oncology, 2022 - Springer
Cancer has been constantly evolving and so is the research pertaining to cancer diagnosis
and therapeutic regimens. Early detection and specific therapeutics are the key features of …

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis

L Cao, TM Lih, Y Hu, M Schnaubelt, SY Chen… - Nature …, 2022 - nature.com
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins
in physiological and pathological processes. However, quantitative characterization of core …

Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer

GP Nagaraju, S Zhu, JE Ko, N Ashritha, R Kandimalla… - Cancer letters, 2015 - Elsevier
Hypoxia-inducible factors (HIFs) and NF-κB play essential roles in cancer cell growth and
metastasis by promoting angiogenesis. Heat shock protein 90 (Hsp90) serves as a regulator …

FN1 encoding fibronectin as a pivotal signaling gene for therapeutic intervention against pancreatic cancer

G Ashok, SK Miryala, MT Saju, A Anbarasu… - Molecular Genetics and …, 2022 - Springer
The delayed diagnosis of pancreatic cancer has resulted in rising mortality rate and low
survival rate that can be circumvented using potent theranostics biomarkers. The treatment …

RNA sequencing analyses reveal novel differentially expressed genes and pathways in pancreatic cancer

Y Mao, J Shen, Y Lu, K Lin, H Wang, Y Li… - …, 2017 - pmc.ncbi.nlm.nih.gov
Gene expression microarrays have identified many tumor markers and therapeutic targets
for pancreatic ductal adenocarcinoma (PDAC). However, microarray profilings have limited …

Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma

K Unger, KY Mehta, P Kaur, Y Wang, SS Menon… - …, 2018 - pmc.ncbi.nlm.nih.gov
The availability of robust classification algorithms for the identification of high risk individuals
with resectable disease is critical to improving early detection strategies and ultimately …

Metabolomic biomarkers of pancreatic cancer: a meta-analysis study

KY Mehta, HJ Wu, SS Menon, Y Fallah, X Zhong… - …, 2017 - pmc.ncbi.nlm.nih.gov
Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is
no blood test for early detection and diagnosis of this disease. Several research groups …

Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus

KM Moore, A Desai, B de Luxán Delgado… - …, 2020 - pmc.ncbi.nlm.nih.gov
Goals of investigation: The 5-year survival rate for pancreatic ductal adenocarcinoma
(PDAC) has remained at< 5% for decades because no effective therapies have been …