Protein analysis by shotgun/bottom-up proteomics

Y Zhang, BR Fonslow, B Shan, MC Baek… - Chemical …, 2013 - ACS Publications
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

[HTML][HTML] Methods, tools and current perspectives in proteogenomics

KV Ruggles, K Krug, X Wang, KR Clauser… - Molecular & Cellular …, 2017 - Elsevier
With combined technological advancements in high-throughput next-generation sequencing
and deep mass spectrometry-based proteomics, proteogenomics, ie the integrative analysis …

DRP1 interacts directly with BAX to induce its activation and apoptosis

A Jenner, A Peña‐Blanco, R Salvador‐Gallego… - The EMBO …, 2022 - embopress.org
The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at
mitochondria during apoptosis to mediate mitochondrial permeabilization and …

A chromosome-based draft sequence of the hexaploid bread wheat (Triticum aestivum) genome

International Wheat Genome Sequencing Consortium … - Science, 2014 - science.org
An ordered draft sequence of the 17-gigabase hexaploid bread wheat (Triticum aestivum)
genome has been produced by sequencing isolated chromosome arms. We have annotated …

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5

SJ Clasen, MEW Bell, A Borbón, DH Lee… - Science …, 2023 - science.org
Flagellin, the protein subunit of the bacterial flagellum, stimulates the innate immune
receptor Toll-like receptor 5 (TLR5) after pattern recognition or evades TLR5 through lack of …

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

F Ikeda, YL Deribe, SS Skånland, B Stieglitz, C Grabbe… - Nature, 2011 - nature.com
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when
mutated in mice, results in immune system disorders and multi-organ inflammation,. Here we …

Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells

K Thomas, L Zondler, N Ludwig, M Kardell… - JCI …, 2022 - pmc.ncbi.nlm.nih.gov
Acute kidney injury (AKI) represents a common complication in critically ill patients that is
associated with increased morbidity and mortality. In a murine AKI model induced by …

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

D Bakula, AJ Müller, T Zuleger, Z Takacs… - Nature …, 2017 - nature.com
Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control
the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for …

[HTML][HTML] Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1

PA Manavella, J Hagmann, F Ott, S Laubinger, M Franz… - Cell, 2012 - cell.com
MicroRNAs (miRNAs) are processed from primary transcripts that contain partially self-
complementary foldbacks. As in animals, the core microprocessor in plants is a Dicer …

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

AS Löffler, S Alers, AM Dieterle, H Keppeler… - Autophagy, 2011 - Taylor & Francis
Unc-51-like kinase 1 (Ulk1) plays a central role in autophagy induction. It forms a stable
complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa …