[HTML][HTML] What is a cell type and how to define it?

H Zeng - Cell, 2022 - cell.com
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Z Yao, CTJ van Velthoven, M Kunst, M Zhang… - Nature, 2023 - nature.com
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification

X Zhang, P Leavey, H Appel, N Makrides… - Trends in Genetics, 2023 - cell.com
This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the develo** retina, with a focus on insights obtained …

Evolution of neuronal cell classes and types in the vertebrate retina

J Hahn, A Monavarfeshani, M Qiao, AH Kao, Y Kölsch… - Nature, 2023 - nature.com
The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in
their visual needs. Retinal cell types may have evolved to accommodate these varied needs …

[HTML][HTML] A single-cell time-lapse of mouse prenatal development from gastrula to birth

C Qiu, BK Martin, IC Welsh, RM Daza, TM Le, X Huang… - Nature, 2024 - nature.com
The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

[HTML][HTML] Cell-type specification in the retina: Recent discoveries from transcriptomic approaches

YR Peng - Current opinion in neurobiology, 2023 - Elsevier
Understanding the formation of the complex nervous system hinges on decoding the
mechanism that specifies a vast array of neuronal types, each endowed with a unique …

The transcription factor Tbx5 regulates direction-selective retinal ganglion cell development and image stabilization

T Al-Khindi, MB Sherman, T Kodama, P Gopal, Z Pan… - Current Biology, 2022 - cell.com
The diversity of visual input processed by the mammalian visual system requires the
generation of many distinct retinal ganglion cell (RGC) types, each tuned to a particular …

Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration

HJ Kim, JM Saikia, KMA Monte, E Ha… - Neuron, 2023 - cell.com
Despite substantial progress in understanding the biology of axon regeneration in the CNS,
our ability to promote regeneration of the clinically important corticospinal tract (CST) after …

Development of the Binocular Circuit

E Herrera, A Chédotal, C Mason - Annual review of …, 2024 - annualreviews.org
Seeing in three dimensions is a major property of the visual system in mammals. The circuit
underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend …

Circuit mechanisms underlying embryonic retinal waves

C Voufo, AQ Chen, BE Smith, R Yan, MB Feller… - elife, 2023 - elifesciences.org
Spontaneous activity is a hallmark of develo** neural systems. In the retina, spontaneous
activity comes in the form of retinal waves, comprised of three stages persisting from …