Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva

A Amann, B de Lacy Costello, W Miekisch… - Journal of breath …, 2014 - iopscience.iop.org
Breath analysis is a young field of research with its roots in antiquity. Antoine Lavoisier
discovered carbon dioxide in exhaled breath during the period 1777–1783, Wilhelm (Vilém) …

Advances in solid phase microextraction and perspective on future directions

N Reyes-Garces, E Gionfriddo… - Analytical …, 2017 - ACS Publications
Solid phase microextraction (SPME) is a versatile, nonex-haustive sample preparation tool
that has been demonstrated to be well-suited for facile and effective analysis of a broad …

Gut microbiota profiling: metabolomics based approach to unravel compounds affecting human health

P Vernocchi, F Del Chierico, L Putignani - Frontiers in microbiology, 2016 - frontiersin.org
The gut microbiota is composed of a huge number of different bacteria, that produce a large
amount of compounds playing a key role in microbe selection and in the construction of a …

A review on human fecal metabolomics: Methods, applications and the human fecal metabolome database

N Karu, L Deng, M Slae, AC Guo, T Sajed, H Huynh… - Analytica chimica …, 2018 - Elsevier
Metabolomic analysis of human biospecimens had progressed quickly over the past
decade. Technological and methodological advances have led to the comprehensive …

Stress and the microbiota–gut–brain axis in visceral pain: relevance to irritable bowel syndrome

RD Moloney, AC Johnson… - CNS neuroscience & …, 2016 - Wiley Online Library
Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

Brain–gut microbiome interactions and functional bowel disorders

EA Mayer, T Savidge, RJ Shulman - Gastroenterology, 2014 - Elsevier
Alterations in the bidirectional interactions between the intestine and the nervous system
have important roles in the pathogenesis of irritable bowel syndrome (IBS). A body of largely …

Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD

T Lee, T Clavel, K Smirnov, A Schmidt, I Lagkouvardos… - Gut, 2017 - gut.bmj.com
Objective Iron deficiency is a common complication in patients with IBD and oral iron therapy
is suggested to exacerbate IBD symptoms. We performed an open-labelled clinical trial to …

Breathing new life into clinical testing and diagnostics: perspectives on volatile biomarkers from breath

JJ Haworth, CK Pitcher, G Ferrandino… - Critical Reviews in …, 2022 - Taylor & Francis
Human breath offers several benefits for diagnostic applications, including simple,
noninvasive collection. Breath is a rich source of clinically-relevant biological information; …

Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe

S Lamichhane, P Sen, AM Dickens, M Orešič… - Methods, 2018 - Elsevier
It is well established that gut microbes and their metabolic products regulate host
metabolism. The interactions between the host and its gut microbiota are highly dynamic …