Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

To chart cell composition and cell state changes that occur during the transformation of
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …

While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …

Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Defining the complex role of the microbiome in colorectal cancer and the discovery of novel,
protumorigenic microbes are areas of active investigation. In the present study, culturing and …

Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality.
Different molecular mechanisms have been attributed to the development and progress of …

Colorectal cancer (CRC) is one of the most common malignant carcinomas. CRC is
characterized by asymptomatic onset, and most patients are already in the middle and …