Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …

Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …

The regulation of gene expression requires a wide array of protein factors that can modulate
chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate …

Poly (ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer
negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide …

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to
expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be …

Acrolein is a highly reactive unsaturated aldehyde that is formed during the burning of
gasoline and diesel fuels, cigarettes, woods and plastics. In addition, acrolein is generated …

SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the
stress protection pathway. SIRT1 deacetylates a number of protein substrates, including …