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RNA-binding proteins in tumor progression
H Qin, H Ni, Y Liu, Y Yuan, T **, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …
important biological functions. They are critical to maintain the transcriptome through post …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
What are 3′ UTRs doing?
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
m6A readers ECT2/ECT3/ECT4 enhance mRNA stability through direct recruitment of the poly(A) binding proteins in Arabidopsis
Background RNA N 6-methyladenosine (m6A) modification is critical for plant growth and
crop yield. m6A reader proteins can recognize m6A modifications to facilitate the functions of …
crop yield. m6A reader proteins can recognize m6A modifications to facilitate the functions of …
Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies
The biological functions of the epitranscriptomic modification N 6-methyladenosine (m 6 A)
in plants are not fully understood. CPSF30-L is a predominant isoform of the polyadenylation …
in plants are not fully understood. CPSF30-L is a predominant isoform of the polyadenylation …
Context-specific regulation and function of mRNA alternative polyadenylation
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
Evolution and biological roles of alternative 3′ UTRs
More than half of human genes use alternative cleavage and polyadenylation to generate
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
Targeting mRNA processing as an anticancer strategy
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Quantifying 3′ UTR length from scRNA-seq data reveals changes independent of gene expression
Although more than half of all genes generate transcripts that differ in 3′ UTR length,
current analysis pipelines only quantify the amount but not the length of mRNA transcripts …
current analysis pipelines only quantify the amount but not the length of mRNA transcripts …