Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
RNA-binding proteins in tumor progression
H Qin, H Ni, Y Liu, Y Yuan, T **, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …
important biological functions. They are critical to maintain the transcriptome through post …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
What are 3′ UTRs doing?
C Mayr - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies
P Song, J Yang, C Wang, Q Lu, L Shi, S Tayier, G Jia - Molecular plant, 2021 - cell.com
The biological functions of the epitranscriptomic modification N 6-methyladenosine (m 6 A)
in plants are not fully understood. CPSF30-L is a predominant isoform of the polyadenylation …
in plants are not fully understood. CPSF30-L is a predominant isoform of the polyadenylation …
Evolution and biological roles of alternative 3′ UTRs
C Mayr - Trends in cell biology, 2016 - cell.com
More than half of human genes use alternative cleavage and polyadenylation to generate
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Context-specific regulation and function of mRNA alternative polyadenylation
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
m6A readers ECT2/ECT3/ECT4 enhance mRNA stability through direct recruitment of the poly(A) binding proteins in Arabidopsis
P Song, L Wei, Z Chen, Z Cai, Q Lu, C Wang, E Tian… - Genome biology, 2023 - Springer
Background RNA N 6-methyladenosine (m6A) modification is critical for plant growth and
crop yield. m6A reader proteins can recognize m6A modifications to facilitate the functions of …
crop yield. m6A reader proteins can recognize m6A modifications to facilitate the functions of …
RNA-binding proteins control gene expression and cell fate in the immune system
RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …
system. They interact dynamically with RNA to control its biogenesis and turnover by …