[HTML][HTML] STAT3 and its targeting inhibitors in oral squamous cell carcinoma

M Jiang, B Li - Cells, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of
oral mucosa and accounts for approximately 90% of oral cancers. Current therapeutic …

An overview of the pharmacological activities of scopoletin against different chronic diseases

D Parama, S Girisa, E Khatoon, A Kumar… - Pharmacological …, 2022 - Elsevier
Chronic diseases are considered a major public health concern worldwide, and most of
these diseases like cancer, cardiovascular, metabolic, and neurological disorders occur due …

Betulinic acid: A natural promising anticancer drug, current situation, and future perspectives

M Aswathy, A Vijayan, UD Daimary… - … of Biochemical and …, 2022 - Wiley Online Library
Natural products serve as the single most productive source for the discovery of drugs and
pharmaceutical leads. Among the various chemicals derived from microbes, plants, and …

Recent progress on triterpenoid derivatives and their anticancer potential

ZX Zhao, QY Zou, YH Ma, SL Morris‐Natschke, XY Li… - Phytochemistry, 2024 - Elsevier
Cancer poses a significant global public health challenge, with commonly used adjuvant or
neoadjuvant chemotherapy often leading to adverse side effects and drug resistance …

The promising potential of piperlongumine as an emerging therapeutics for cancer

D Parama, V Rana, S Girisa, E Verma… - … of Targeted Anti …, 2021 - pmc.ncbi.nlm.nih.gov
In spite of the immense advancement in the diagnostic and treatment modalities, cancer
continues to be one of the leading causes of mortality across the globe, responsible for the …

A mass spectrometry database for the identification of marine animal saponin-related metabolites

SJ Smith, SF Cummins, CA Motti, T Wang - Analytical and Bioanalytical …, 2024 - Springer
Saponins encompass a diverse group of naturally occurring glycoside molecules exhibiting
amphiphilic properties and a broad range of biological activities. There is a resurgence of …

Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

BL Sailo, S Chauhan, M Hegde, S Girisa… - Phytotherapy …, 2024 - Wiley Online Library
Chemoresistance is the adaptation of cancer cells against therapeutic agents. When
exhibited by cancer cells, chemoresistance helps them to avoid apoptosis, cause relapse …

Targeted inhibition of colorectal cancer proliferation: The dual‐modulatory role of 2, 4‐DTBP on anti‐apoptotic Bcl‐2 and Survivin proteins

P Saha, M Hegde, K Chakraborty… - Journal of Cellular …, 2024 - Wiley Online Library
The anti‐apoptotic proteins, Bcl‐2 and Survivin, are consistently overexpressed in numerous
human malignancies, notably in colorectal cancer. 2, 4‐Di‐tert‐butylphenol (2, 4‐DTBP) is a …

Natural Prenylflavones from the Stem Bark of Artocarpus altilis: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 …

M Aswathy, D Parama, M Hegde, S DR… - ACS …, 2024 - ACS Publications
Artonin E (AA2) and artobiloxanthone (AA3) were extracted and purified from the acetone
extract of the stem bark of Artocarpus altilis (Parkinson) Fosberg. Preliminary investigations …

Synergistic enhancement: Exploring the potential of piperine in cancer therapeutics through chemosensitization and combination therapies

MK Manickasamy, A Kumar, B BharathwajChetty… - Life Sciences, 2024 - Elsevier
Despite significant advancements in chemotherapy, effective treatments for advanced
cancer stages remain largely elusive due to chemoresistance. Resistance to anticancer …