Constructing custom thermodynamics using deep learning

X Chen, BW Soh, ZE Ooi, E Vissol-Gaudin… - Nature Computational …, 2024 - nature.com
One of the most exciting applications of artificial intelligence is automated scientific
discovery based on previously amassed data, coupled with restrictions provided by known …

Effect of molecular architecture on ring polymer dynamics in semidilute linear polymer solutions

Y Zhou, KW Hsiao, KE Regan, D Kong… - Nature …, 2019 - nature.com
Understanding the dynamics of ring polymers is a particularly challenging yet interesting
problem in soft materials. Despite recent progress, a complete understanding of the …

Motion of knots in DNA stretched by elongational fields

AR Klotz, BW Soh, PS Doyle - Physical review letters, 2018 - APS
Knots in DNA occur in biological systems, serve as a model system for polymer
entanglement, and affect the efficacy of modern genomics technologies. We study the …

Diffusion of knots along DNA confined in nanochannels

Z Ma, KD Dorfman - Macromolecules, 2020 - ACS Publications
We study the diffusion of knots along relaxed deoxyribonucleic acid (DNA) in nanochannels
using a nanofluidic “knot factory” device for knot generation. The apparent scaling exponent …

Topology, geometry, and mechanics of strongly stretched and twisted filaments: solenoids, plectonemes, and artificial muscle fibers

N Charles, M Gazzola, L Mahadevan - Physical review letters, 2019 - APS
Soft elastic filaments that can be stretched, bent, and twisted exhibit a range of topologically
and geometrically complex morphologies. Recently, a number of experiments have shown …

[HTML][HTML] Dynamics and rheology of ring-linear blend semidilute solutions in extensional flow: Single molecule experiments

Y Zhou, CD Young, M Lee, S Banik, D Kong… - Journal of …, 2021 - pubs.aip.org
Ring polymers exhibit unique flow properties due to their closed chain topology. Despite
recent progress, we have not yet achieved a full understanding of the nonequilibrium flow …

Single-molecule analysis of DNA structures using nanopore sensors

LI Fu-Yao, LUO Yu-Han, XI Guo-Hao, FU Ji-Ye… - Chinese Journal of …, 2022 - Elsevier
Nanopore has been studied for a lot of applications in DNA sequencing, multifarious single-
molecule detection, detection of molecular conformational change, and biomolecular …

Long-lived self-entanglements in ring polymers

BW Soh, AR Klotz, RM Robertson-Anderson, PS Doyle - Physical review letters, 2019 - APS
The entanglement of ring polymers remains mysterious in many aspects. In this Letter, we
use electric fields to induce self-entanglements in circular DNA molecules, which serve as a …

Equilibrium conformation of catenated DNA networks in slitlike confinement

BW Soh, PS Doyle - ACS Macro Letters, 2021 - ACS Publications
A kinetoplast is a planar network of catenated DNA rings with topology that resembles that of
chain mail armor. In this work, we use single-molecule experiments to probe the …

Deformation response of catenated DNA networks in a planar elongational field

BW Soh, PS Doyle - ACS Macro Letters, 2020 - ACS Publications
A kinetoplast is a complex catenated DNA network that bears resemblance to a two-
dimensional polymeric system. In this work, we use single-molecule experiments to study …