ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression

S Zhang, F Yang, Y Huang, L He, Y Li, YCE Wan… - Nature …, 2023 - nature.com
Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …

[HTML][HTML] Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality

SC Schüler, JM Kirkpatrick, M Schmidt, D Santinha… - Cell reports, 2021 - cell.com
During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …

PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase

X Tao, R Du, S Guo, X Feng, T Yu, Q OuYang… - The EMBO …, 2022 - embopress.org
Brown adipose tissue (BAT) functions as a thermogenic organ and is negatively associated
with cardiometabolic diseases. N6‐methyladenosine (m6A) modulation regulates the fate of …

Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality

H Henze, SS Hüttner, P Koch, SC Schüler… - NPJ Regenerative …, 2024 - nature.com
Skeletal muscle function crucially depends on innervation while repair of skeletal muscle
relies on resident muscle stem cells (MuSCs). However, it is poorly understood how …

[HTML][HTML] Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations

M Triolo, S Wade, N Baker, M Khacho - STAR protocols, 2023 - Elsevier
Since changes in mitochondrial morphology regulate key functions of stem cells, it is
important to assess their structure under physiological and pathophysiological conditions …

Wnt7a counteracts cancer cachexia

M Schmidt, C Poser, J von Maltzahn - Molecular Therapy-Oncolytics, 2020 - cell.com
Cancer cachexia is a complex metabolic disease so far lacking effective therapy, and it
accounts for approximately one third of all cancer-related deaths worldwide. The …

RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle regeneration

E Catalani, S Zecchini, M Giovarelli, A Cherubini… - Cell Death …, 2022 - nature.com
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells,
namely satellite cells (SC). Despite numerous mechanisms have been described, different …

Vitamin D/vitamin D receptor signaling attenuates skeletal muscle atrophy by suppressing renin‐angiotensin system

WX Li, XH Qin, CCW Poon, MS Wong… - Journal of Bone and …, 2020 - academic.oup.com
The nutritional level of vitamin D may affect musculoskeletal health. We have reported that
vitamin D is a pivotal protector against tissue injuries by suppressing local renin‐angiotensin …

Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor

S Yuan, S Zheng, K Zheng, Y Gao, M Chen… - Stem Cell Research & …, 2021 - Springer
Background and objective Sympathetic activity plays an important role in the proliferation
and differentiation of stem cells, and it changes over time, thereby exerting differential effects …

Stimulation of non-canonical NF-κB through lymphotoxin-β-receptor impairs myogenic differentiation and regeneration of skeletal muscle

M Schmidt, A Weidemann, C Poser, A Bigot… - Frontiers in Cell and …, 2021 - frontiersin.org
Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle
are cellular processes under tight control of various signaling pathways. Here, we …