ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …
[HTML][HTML] Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
SC Schüler, JM Kirkpatrick, M Schmidt, D Santinha… - Cell reports, 2021 - cell.com
During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase
X Tao, R Du, S Guo, X Feng, T Yu, Q OuYang… - The EMBO …, 2022 - embopress.org
Brown adipose tissue (BAT) functions as a thermogenic organ and is negatively associated
with cardiometabolic diseases. N6‐methyladenosine (m6A) modulation regulates the fate of …
with cardiometabolic diseases. N6‐methyladenosine (m6A) modulation regulates the fate of …
Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality
Skeletal muscle function crucially depends on innervation while repair of skeletal muscle
relies on resident muscle stem cells (MuSCs). However, it is poorly understood how …
relies on resident muscle stem cells (MuSCs). However, it is poorly understood how …
[HTML][HTML] Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations
Since changes in mitochondrial morphology regulate key functions of stem cells, it is
important to assess their structure under physiological and pathophysiological conditions …
important to assess their structure under physiological and pathophysiological conditions …
Wnt7a counteracts cancer cachexia
M Schmidt, C Poser, J von Maltzahn - Molecular Therapy-Oncolytics, 2020 - cell.com
Cancer cachexia is a complex metabolic disease so far lacking effective therapy, and it
accounts for approximately one third of all cancer-related deaths worldwide. The …
accounts for approximately one third of all cancer-related deaths worldwide. The …
RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle regeneration
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells,
namely satellite cells (SC). Despite numerous mechanisms have been described, different …
namely satellite cells (SC). Despite numerous mechanisms have been described, different …
Vitamin D/vitamin D receptor signaling attenuates skeletal muscle atrophy by suppressing renin‐angiotensin system
WX Li, XH Qin, CCW Poon, MS Wong… - Journal of Bone and …, 2020 - academic.oup.com
The nutritional level of vitamin D may affect musculoskeletal health. We have reported that
vitamin D is a pivotal protector against tissue injuries by suppressing local renin‐angiotensin …
vitamin D is a pivotal protector against tissue injuries by suppressing local renin‐angiotensin …
Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor
S Yuan, S Zheng, K Zheng, Y Gao, M Chen… - Stem Cell Research & …, 2021 - Springer
Background and objective Sympathetic activity plays an important role in the proliferation
and differentiation of stem cells, and it changes over time, thereby exerting differential effects …
and differentiation of stem cells, and it changes over time, thereby exerting differential effects …
Stimulation of non-canonical NF-κB through lymphotoxin-β-receptor impairs myogenic differentiation and regeneration of skeletal muscle
M Schmidt, A Weidemann, C Poser, A Bigot… - Frontiers in Cell and …, 2021 - frontiersin.org
Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle
are cellular processes under tight control of various signaling pathways. Here, we …
are cellular processes under tight control of various signaling pathways. Here, we …