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Barriers and strategies to achieve a cure for HIV
9 years since the report of a cure for HIV after CC chemokine receptor type 5 Δ32 stem cell
transplantation, no other case of HIV cure has been reported, despite much research …
transplantation, no other case of HIV cure has been reported, despite much research …
Modelling HIV-1 control and remission
Remarkable advances are being made in develo** interventions for eliciting long-term
remission of HIV-1 infection. The success of these interventions will obviate the need for …
remission of HIV-1 infection. The success of these interventions will obviate the need for …
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation
A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago,.
The individual—who is known as the 'Berlin patient'—underwent two allogeneic …
The individual—who is known as the 'Berlin patient'—underwent two allogeneic …
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells
HIV cure has been reported for five individuals who underwent allogeneic hematopoietic
stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By …
stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By …
Clones of infected cells arise early in HIV-infected individuals
In HIV-infected individuals on long-term antiretroviral therapy (ART), more than 40% of the
infected cells are in clones. Although most HIV proviruses present in individuals on long …
infected cells are in clones. Although most HIV proviruses present in individuals on long …
Digital PCR as a tool to measure HIV persistence
Although antiretroviral therapy is able to suppress HIV replication in infected patients, the
virus persists and rebounds when treatment is stopped. In order to find a cure that can …
virus persists and rebounds when treatment is stopped. In order to find a cure that can …
Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective …
Background Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) markedly
reduces HIV reservoirs, but the mechanisms by which this occurs are only partly understood …
reduces HIV reservoirs, but the mechanisms by which this occurs are only partly understood …
HIV cure: The daunting scale of the problem
JD Siliciano, RF Siliciano - Science, 2024 - science.org
Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels
such that clinical assays for viremia are negative. Because of unexpected cooperativity in …
such that clinical assays for viremia are negative. Because of unexpected cooperativity in …
Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates
Chimeric antigen receptor (CAR) T cells targeting CD19+ hematologic malignancies have
rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell …
rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell …
Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir
Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of
latently infected cells harboring replication-competent proviruses. Measuring persistent HIV …
latently infected cells harboring replication-competent proviruses. Measuring persistent HIV …