Barriers and strategies to achieve a cure for HIV

MC Pitman, JSY Lau, JH McMahon, SR Lewin - The Lancet HIV, 2018 - thelancet.com
9 years since the report of a cure for HIV after CC chemokine receptor type 5 Δ32 stem cell
transplantation, no other case of HIV cure has been reported, despite much research …

Modelling HIV-1 control and remission

B Vemparala, S Chowdhury, J Guedj… - NPJ systems biology and …, 2024 - nature.com
Remarkable advances are being made in develo** interventions for eliciting long-term
remission of HIV-1 infection. The success of these interventions will obviate the need for …

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

RK Gupta, S Abdul-Jawad, LE McCoy, HP Mok… - Nature, 2019 - nature.com
A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago,.
The individual—who is known as the 'Berlin patient'—underwent two allogeneic …

Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells

A Sáez-Cirión, AC Mamez, V Avettand-Fenoel… - Nature medicine, 2024 - nature.com
HIV cure has been reported for five individuals who underwent allogeneic hematopoietic
stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By …

Clones of infected cells arise early in HIV-infected individuals

JM Coffin, DW Wells, JM Zerbato, JD Kuruc, S Guo… - JCI …, 2019 - pmc.ncbi.nlm.nih.gov
In HIV-infected individuals on long-term antiretroviral therapy (ART), more than 40% of the
infected cells are in clones. Although most HIV proviruses present in individuals on long …

Digital PCR as a tool to measure HIV persistence

S Rutsaert, K Bosman, W Trypsteen, M Nijhuis… - Retrovirology, 2018 - Springer
Although antiretroviral therapy is able to suppress HIV replication in infected patients, the
virus persists and rebounds when treatment is stopped. In order to find a cure that can …

Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective …

M Salgado, C Gálvez, M Nijhuis, M Kwon… - The Lancet …, 2024 - thelancet.com
Background Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) markedly
reduces HIV reservoirs, but the mechanisms by which this occurs are only partly understood …

HIV cure: The daunting scale of the problem

JD Siliciano, RF Siliciano - Science, 2024 - science.org
Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels
such that clinical assays for viremia are negative. Because of unexpected cooperativity in …

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

BJ Rust, LS Kean, L Colonna… - Blood, The Journal …, 2020 - ashpublications.org
Chimeric antigen receptor (CAR) T cells targeting CD19+ hematologic malignancies have
rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell …

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir

Z Wang, FR Simonetti, RF Siliciano, GM Laird - Retrovirology, 2018 - Springer
Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of
latently infected cells harboring replication-competent proviruses. Measuring persistent HIV …