Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer
development and progression and an important determinant of cancer therapeutic …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye.
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Major advances in our understanding of cancer pathogenesis and therapy have come from
efforts to catalog genomic alterations in cancer. A growing number of large-scale genomic …

SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which
are clonal hematopoietic disorders with variable risk of leukemic transformation. Although …

Genetic networks are characterized by extensive buffering. During tumor evolution,
disruption of functional redundancies can create de novo vulnerabilities that are specific to …