Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

Cell-to-cell communication happens via diverse mechanisms including the synthesis,
release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles …

Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

Clinical type 1 diabetes is preceded by an asymptomatic phase that can be identified by
serum islet autoantibodies. This perspective proposes that there is now sufficient evidence …

Gelsolin, an actin-depolymerizing protein expressed both in extracellular fluids and in the
cytoplasm of a majority of human cells, has been recently implicated in a variety of both …

Extracellular vesicles play major roles in cell-to-cell communication and are excellent
biomarker candidates. However, studying plasma extracellular vesicles is challenging due …

Summary Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient
availability of biomarkers represents a significant gap in understanding the disease cause …