Molecular mechanisms and physiological importance of circadian rhythms

A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism

OH Meléndez-Fernández, JA Liu… - International journal of …, 2023 - mdpi.com
Availability of artificial light and light-emitting devices have altered human temporal life,
allowing 24-hour healthcare, commerce and production, and expanding social life around …

[HTML][HTML] Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer's disease

DS Whittaker, L Akhmetova, D Carlin, H Romero… - Cell metabolism, 2023 - cell.com
Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …

Circadian rhythm as a therapeutic target

W Ruan, X Yuan, HK Eltzschig - Nature Reviews Drug Discovery, 2021 - nature.com
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Magnetic field effects in biology from the perspective of the radical pair mechanism

H Zadeh-Haghighi, C Simon - Journal of the Royal …, 2022 - royalsocietypublishing.org
Hundreds of studies have found that weak magnetic fields can significantly influence various
biological systems. However, the underlying mechanisms behind these phenomena remain …

Time-restricted eating to prevent and manage chronic metabolic diseases

A Chaix, ENC Manoogian, GC Melkani… - Annual review of …, 2019 - annualreviews.org
Molecular clocks are present in almost every cell to anticipate daily recurring and
predictable changes, such as rhythmic nutrient availability, and to adapt cellular functions …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Circadian clock genes and the transcriptional architecture of the clock mechanism

KH Cox, JS Takahashi - Journal of molecular endocrinology, 2019 - jme.bioscientifica.com
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Circadian physiology of metabolism

S Panda - Science, 2016 - science.org
A majority of mammalian genes exhibit daily fluctuations in expression levels, making
circadian expression rhythms the largest known regulatory network in normal physiology …

The emerging link between cancer, metabolism, and circadian rhythms

S Masri, P Sassone-Corsi - Nature medicine, 2018 - nature.com
The circadian clock is a complex cellular mechanism that, through the control of diverse
metabolic and gene expression pathways, governs a large array of cyclic physiological …