Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future
A Chanpong, N Thapar - Journal of Pediatric Gastroenterology …, 2023 - journals.lww.com
The field of pediatric neurogastroenterology and motility encompasses some of the most
common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders …
common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders …
How to heal the gut's brain: regeneration of the enteric nervous system
H Rueckert, J Ganz - International Journal of Molecular Sciences, 2022 - mdpi.com
The neural-crest-derived enteric nervous system (ENS) is the intrinsic nervous system of the
gastrointestinal (GI) tract and controls all gut functions, including motility. Lack of ENS …
gastrointestinal (GI) tract and controls all gut functions, including motility. Lack of ENS …
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA‐induced MEK1/2 signaling pathway
D Tian, W Xu, W Pan, B Zheng, W Yang, W Jia… - The EMBO …, 2023 - embopress.org
Hirschsprung disease (HSCR), one of several neurocristopathies in children, is
characterized by nerve loss in the large intestine and is mainly treated by surgery, which …
characterized by nerve loss in the large intestine and is mainly treated by surgery, which …
Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice
Background Enteric neuropathies, which result from abnormalities of the enteric nervous
system, are associated with significant morbidity and high health-care costs, but current …
system, are associated with significant morbidity and high health-care costs, but current …
Autologous cell transplantation for treatment of colorectal aganglionosis in mice
Neurointestinal diseases cause significant morbidity and effective treatments are lacking.
This study aimes to test the feasibility of transplanting autologous enteric neural stem cells …
This study aimes to test the feasibility of transplanting autologous enteric neural stem cells …
Evaluating the molecular and genetic mechanisms underlying gut motility disorders
A Chanpong, MM Alves, E Bonora… - Expert Review of …, 2023 - Taylor & Francis
Introduction Gastrointestinal (GI) motility disorders comprise a wide range of different
diseases affecting the structural or functional integrity of the GI neuromusculature. Their …
diseases affecting the structural or functional integrity of the GI neuromusculature. Their …
Enteric neural stem cell transplant restores gut motility in mice with Hirschsprung disease
The goal of this study was to determine if transplantation of enteric neural stem cells
(ENSCs) can rescue the enteric nervous system, restore gut motility, reduce colonic …
(ENSCs) can rescue the enteric nervous system, restore gut motility, reduce colonic …
Tissue engineering and regenerative medicine approaches in colorectal surgery
BB Mainali, JJ Yoo, MR Ladd - Annals of Coloproctology, 2024 - pmc.ncbi.nlm.nih.gov
Tissue engineering and regenerative medicine (TERM) is an emerging field that has
provided new therapeutic opportunities by delivering innovative solutions. The development …
provided new therapeutic opportunities by delivering innovative solutions. The development …
[HTML][HTML] Identifying the potential transcriptional regulatory network in Hirschsprung disease by integrated analysis of microarray datasets
W Xu, H Yu, D Chen, W Pan, W Yang… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Objective Hirschsprung disease (HSCR) is one of the common neurocristopathies in
children, which is associated with at least 20 genes and involves a complex regulatory …
children, which is associated with at least 20 genes and involves a complex regulatory …
Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders
K Yoshimaru, T Matsuura, Y Uchida, S Sonoda… - Surgery today, 2024 - Springer
Hirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in
severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy …
severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy …