Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response
To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The
number of clinical trials that can be performed is limited. We developed mathematical …
number of clinical trials that can be performed is limited. We developed mathematical …
Systematic inference identifies a major source of heterogeneity in cell signaling dynamics: The rate-limiting step number
Identifying the sources of cell-to-cell variability in signaling dynamics is essential to
understand drug response variability and develop effective therapeutics. However, it is …
understand drug response variability and develop effective therapeutics. However, it is …
Mathematical modeling of variability in intracellular signaling
Cellular signaling is essential in information processing and decision-making. Therefore, a
variety of experimental approaches have been developed to study signaling on bulk and …
variety of experimental approaches have been developed to study signaling on bulk and …
What population reveals about individual cell identity: single-cell parameter estimation of models of gene expression in yeast
A Llamosi, AM Gonzalez-Vargas… - PLoS computational …, 2016 - journals.plos.org
Significant cell-to-cell heterogeneity is ubiquitously observed in isogenic cell populations.
Consequently, parameters of models of intracellular processes, usually fitted to population …
Consequently, parameters of models of intracellular processes, usually fitted to population …
Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research
Microphysiological systems (MPS) are powerful tools for emulating human physiology and
replicating disease progression in vitro. MPS could be better predictors of human outcome …
replicating disease progression in vitro. MPS could be better predictors of human outcome …
Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions
B Costa, N Vale - International Journal of Molecular Sciences, 2023 - mdpi.com
This review investigates the intricate role of human endogenous retroviruses (HERVs) in
cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper …
cancer development and progression, explicitly focusing on HERV-K (HML-2). This paper …
Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaques
In clinical trials, remdesivir decreased recovery time in hospitalized patients with SARS-CoV-
2 and prevented hospitalization when given early during infection, despite not reducing …
2 and prevented hospitalization when given early during infection, despite not reducing …
[HTML][HTML] A mathematical model of the within-host kinetics of SARS-CoV-2 neutralizing antibodies following COVID-19 vaccination
L dePillis, R Caffrey, G Chen, MD Dela… - Journal of Theoretical …, 2023 - Elsevier
Compelling evidence continues to build to support the idea that SARS-CoV-2 Neutralizing
Antibody (NAb) levels in an individual can serve as an important indicator of the strength of …
Antibody (NAb) levels in an individual can serve as an important indicator of the strength of …
Modeling early treatment response in AML from cell-free tumor DNA
Monitoring disease response after intensive chemotherapy for acute myeloid leukemia
(AML) currently requires invasive bone marrow biopsies, imposing a significant burden on …
(AML) currently requires invasive bone marrow biopsies, imposing a significant burden on …
Fine-Tuning of Energy Levels Regulates SUC2 via a SNF1-Dependent Feedback Loop
Nutrient sensing pathways are playing an important role in cellular response to different
energy levels. In budding yeast, Saccharomyces cerevisiae, the sucrose non-fermenting …
energy levels. In budding yeast, Saccharomyces cerevisiae, the sucrose non-fermenting …