Dihydropyrimidines are the most important heterocyclic ring systems which play an
important role in the synthesis of DNA and RNA. Synthetically they were synthesized using …

Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3, 4-
dihydropyrimidin-2 (1H)-ones/thiones (DHPMs) have emerged as prototypes for the design …

The present work describes the synthesis, characterization, and application of a new ion‐
tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive …

The Biginelli product, dihydropyrimidinone (DHPM) core, and its derivatives are of immense
biological importance. There are several methods reported as modifications to the original …

Cancer is considered as one of the most serious health problems. Despite the presence of
many effective chemotherapeutic agents, their severe side effects together with the …

Herein, a combination of heteropolyacids and ionic liquids as a catalytic system was studied
for the Biginelli multicomponent reaction; the positive ionic liquid effect associated with the …

Background: This review elaborates the updated synthetic and pharmacological approaches
of a known group of dihydropyrimidinones/thiones from the multi-component reaction like …

A series of trifluoromethylated hexahydropyrimidine and tetrahydropyrimidine derivatives
were synthesized and their in vitro cytotoxic activities were determined in colon cancer cell …

A series of dihydropyrimidinone derivatives bearing various N-heterocyclic moieties was
designed and synthesized. Twelve new compounds were screened for their cytotoxic activity …