Understudied proteins: opportunities and challenges for functional proteomics
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …
focused on a limited set of increasingly well-known proteins while the biological functions of …
ANEW APPROACH TO DECODING LIFE: Systems Biology
▪ Abstract Systems biology studies biological systems by systematically perturbing them
(biologically, genetically, or chemically); monitoring the gene, protein, and informational …
(biologically, genetically, or chemically); monitoring the gene, protein, and informational …
The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
Cellular life depends on a complex web of functional associations between biomolecules.
Among these associations, protein–protein interactions are particularly important due to their …
Among these associations, protein–protein interactions are particularly important due to their …
STRING v10: protein–protein interaction networks, integrated over the tree of life
The many functional partnerships and interactions that occur between proteins are at the
core of cellular processing and their systematic characterization helps to provide context in …
core of cellular processing and their systematic characterization helps to provide context in …
Comparative assessment of large-scale data sets of protein–protein interactions
Comprehensive protein–protein interaction maps promise to reveal many aspects of the
complex regulatory network underlying cellular function. Recently, large-scale approaches …
complex regulatory network underlying cellular function. Recently, large-scale approaches …
Functional discovery via a compendium of expression profiles
TR Hughes, MJ Marton, AR Jones, CJ Roberts… - Cell, 2000 - cell.com
Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental
problem in biology. Here, we describe how a single assay can be used to monitor hundreds …
problem in biology. Here, we describe how a single assay can be used to monitor hundreds …
Evidence for dynamically organized modularity in the yeast protein–protein interaction network
In apparently scale-free protein–protein interaction networks, or 'interactome'networks,, most
proteins interact with few partners, whereas a small but significant proportion of proteins, the …
proteins interact with few partners, whereas a small but significant proportion of proteins, the …
[BOOK][B] Clustering
R Xu, D Wunsch - 2008 - books.google.com
This is the first book to take a truly comprehensive look at clustering. It begins with an
introduction to cluster analysis and goes on to explore: proximity measures; hierarchical …
introduction to cluster analysis and goes on to explore: proximity measures; hierarchical …
[BOOK][B] Bioinformatics: the machine learning approach
A guide to machine learning approaches and their application to the analysis of biological
data. An unprecedented wealth of data is being generated by genome sequencing projects …
data. An unprecedented wealth of data is being generated by genome sequencing projects …
Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases
The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …