The role and mechanisms of action of microRNAs in cancer drug resistance

W Si, J Shen, H Zheng, W Fan - Clinical epigenetics, 2019 - Springer
MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis

Y Yang, Z Zhang, S Li, X Ye, X Li, K He - Fitoterapia, 2014 - Elsevier
Herbal medicine, especially traditional Chinese medicine and Ayurvedic medicine have
played and still play an important role in fighting against various diseases. Emerging clinical …

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

CL Au Yeung, NN Co, T Tsuruga, TL Yeung… - Nature …, 2016 - nature.com
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum.
However, the omental stromal cell-derived molecular determinants that modulate ovarian …

Comprehensive analysis of microRNA (miRNA) in cancer cells

N Kanwal, OR Al Samarrai, HMH Al-Zaidi… - Cellular, Molecular …, 2023 - cmbr-journal.com
MicroRNAs (miRNA) are a group of small non-coding RNAs that regulate gene expression
at the RNA level. MicroRNAs have positive regulatory effects on protein translation …

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

P Zheng, L Chen, X Yuan, Q Luo, Y Liu, G **e… - Journal of experimental …, 2017 - Springer
Background Cisplatin-based chemotherapy is frequently used to treat advanced gastric
cancer (GC). However, the resistance often occurs with the mechanisms being not well …

The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells

CPR Xavier, DC Belisario, R Rebelo, YG Assaraf… - Drug Resistance …, 2022 - Elsevier
Drug resistance remains a major hurdle to successful cancer treatment, being accountable
for approximately 90% of cancer-related deaths. In the past years, increasing attention has …

The role of microRNAs in colorectal cancer

A Mohammadi, B Mansoori, B Baradaran - Biomedicine & …, 2016 - Elsevier
Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of
CRC tumorigenesis has been widely studied at the molecular levels, and has been recently …

Arsenic-induced changes in miRNA expression in cancer and other diseases

APF Cardoso, KT Udoh, JC States - Toxicology and applied pharmacology, 2020 - Elsevier
Abstract miRNAs (miRNA) are essential players regulating gene expression affecting
cellular processes contributing to disease development. Dysregulated miRNA expression …

miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells

D Chen, W Si, J Shen, C Du, W Lou, C Bao… - Cell death & …, 2018 - nature.com
Drug resistance remains a major problem in the treatment of conventional chemotherapeutic
agents in breast cancers. Owing to heterogeneity and complexity of chemoresistance …

The network of non-coding RNAs in cancer drug resistance

F Corrà, C Agnoletto, L Minotti, F Baldassari… - Frontiers in …, 2018 - frontiersin.org
Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption
of their function through somatic mutations, genomic imprinting, transcriptional and post …