The mutant selection window hypothesis postulates that, for each antimicrobial-pathogen
combination, an antimicrobial concentration range exists in which selective amplification of …

In spite of the development and wide use of antibiotics, pneumonia is still the leading cause
of infection-related mortality worldwide (101), and antibiotic resistance in the major …

The pharmacodynamic properties governing the activities of antibiotics against intracellular
Staphylococcus aureus are still largely undetermined. Sixteen antibiotics of seven different …

Garenoxacin (GRNX) is a novel des-F (6)-fluoroquinolone on the horizon; thus, its fate and
risk in the aquatic environment deserve attention. This study systematically investigated, for …

H. pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric
cancer. Fluoroquinolones such as levofloxacin, or more recently moxifloxacin or sitafloxacin …

Objectives: Quinolones accumulate in eukaryotic cells and show activity against a large
array of intracellular organisms, but systematic studies aimed at examining their …

A facile and practical approach for the difluoromethylation of phenols and thiophenols was
described. Making use of the recently developed bench-stable S-(difluoromethyl) sulfonium …

Abstract Background Nepal and Bangladesh have a high prevalence of Helicobacter pylori
with high resistance rates to clarithromycin, metronidazole, and levofloxacin. Here, we …

Gateways to clinical trials is a guide to the most recent clinical trials in current literature and
congresses. The data in the following tables has been retrieved from the Clinical Studies …

Study Objective To investigate oseltamivir and oseltamivir carboxylate pharmacokinetics in
critically ill patients who were receiving continuous venovenous hemodialysis (CVVHD) …