Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk
factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have …

▪ Abstract The neurological mutant mouse reeler has played a critical role in the evolution of
our understanding of normal brain development. From the earliest neuroanatomic studies of …

The cerebral cortex of large mammals undergoes massive surface area expansion and
folding during development. Specific mechanisms to orchestrate the growth of the cortex in …

A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor
protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development …

Cajal-Retzius cells are critical in cortical lamination, but very little is known about their origin
and development. The homeodomain transcription factor Dbx1 is expressed in restricted …

Accumulation of neurobiological knowledge points to neurodevelopmental origins for certain
psychotic and mood disorders. Recent landmark postmortem reports implicate Reelin, a …

Size and folding of the cerebral cortex increased massively during mammalian evolution
leading to the current diversity of brain morphologies. Various subtypes of neural stem and …

The development of distinct cellular layers and precise synaptic circuits is essential for the
formation of well functioning cortical structures in the mammalian brain. The extracellular …

GABAergic interneurons have major roles in hippocampal function and dysfunction. Here we
provide evidence that, in mice, virtually all of these cells originate from progenitors in the …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …