Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Antivenom preclinical efficacy testing against Asian snakes and their availability in Asia: A systematic review

S Soopairin, C Patikorn, S Taychakhoonavudh - PLoS One, 2023 - journals.plos.org
Background Cross-neutralizing strategy has been applied to improve access to antivenoms,
a key to reducing mortality and disability of snakebite envenoming. However, preclinical …

High-throughput venomics

J Slagboom, RJE Derks, R Sadighi… - Journal of Proteome …, 2023 - ACS Publications
In this study, we present high-throughput (HT) venomics, a novel analytical strategy capable
of performing a full proteomic analysis of a snake venom within 3 days. This methodology …

[HTML][HTML] Analytical strategies in venomics

J Slagboom, C Kaal, A Arrahman, FJ Vonk… - Microchemical …, 2022 - Elsevier
Snakebite envenoming is a major issue in certain develo** parts of the world, with tens of
thousands of deaths and a multitude of lingering permanent medical conditions on a yearly …

[HTML][HTML] Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance

JJ Calvete, B Lomonte, AJ Saviola, F Bonilla, M Sasa… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human
lives annually worldwide. Snakebite occurs as the result of an interaction between a human …

[HTML][HTML] Proteomics and antivenom immunoprofiling of Russell's viper (Daboia siamensis) venoms from Thailand and Indonesia

TMC Lingam, KY Tan, CH Tan - Journal of Venomous Animals and …, 2020 - SciELO Brasil
Background The Eastern Russell's viper, Daboia siamensis, is a WHO Category 1 medically
important venomous snake. It has a wide but disjunct distribution in Southeast Asia. The …

[HTML][HTML] Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell's viper (Daboia russelii) venoms

T Faisal, KY Tan, NH Tan, SM Sim… - Journal of Venomous …, 2021 - SciELO Brasil
Abstract Background: The western Russell's viper (Daboia russelii) is widely distributed in
South Asia, and geographical venom variation is anticipated among distant populations …

Proteomic insights into short neurotoxin-driven, highly neurotoxic venom of Philippine cobra (Naja philippinensis) and toxicity correlation of cobra envenomation in …

CH Tan, KY Wong, HP Chong, NH Tan, KY Tan - Journal of proteomics, 2019 - Elsevier
Abstract The Philippine cobra, Naja philippinensis, is a WHO Category 1 venomous snake of
medical importance responsible for fatal envenomation in the northern Philippines. To …

Venom composition of Trimeresurus albolabris, T. insularis, T. puniceus and T. purpureomaculatus from Indonesia

S Anita, AR Sadjuri, L Rahmah, HA Nugroho… - Journal of Venomous …, 2022 - SciELO Brasil
Background: Several studies have been published on the characterization of Trimeresurus
venoms. However, there is still limited information concerning the venom composition of …

Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme …

A Chowdhury, CN Zdenek, JS Dobson, LA Bourke… - Toxicology Letters, 2021 - Elsevier
Species within the viperid genus Macrovipera are some of the most dangerous snakes in the
Eurasian region, injecting copious amounts of potent venom. Despite their medical …