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Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance
X Zhang, X Yu - Frontiers in Pharmacology, 2023 - frontiersin.org
Wnt signaling plays an important role in regulating the biological behavior of cancers, and
many drugs targeting this signaling have been developed. Recently, a series of research …
many drugs targeting this signaling have been developed. Recently, a series of research …
Organoids in ovarian cancer: a platform for disease modeling, precision medicine, and drug assessment
H Hu, C Sun, J Chen, Z Li - Journal of Cancer Research and Clinical …, 2024 - Springer
Ovarian cancer (OC) is a major cause of gynecological cancer mortality, necessitating
enhanced research. Organoids, cellular clusters grown in 3D model, have emerged as a …
enhanced research. Organoids, cellular clusters grown in 3D model, have emerged as a …
Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells
Ovarian cancer is a leading cause of death among gynecologic tumors, often detected at
advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors …
advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors …
Aberrant angiogenic signaling pathways: accomplices in ovarian cancer progression and treatment
W Zhou, T Zeng, J Chen, X Tang, Y Yuan, D Hu… - Cellular …, 2024 - Elsevier
Ovarian cancer is one of the most common malignant tumors in women, and treatment
options are limited. Despite efforts to adjust cancer treatment models and develop new …
options are limited. Despite efforts to adjust cancer treatment models and develop new …
Research progress on the application of organoids in gynecological tumors
Y Shen, Y Wang, S Wang, C Li, FJ Han - Frontiers in Pharmacology, 2024 - frontiersin.org
Organoids are in vitro 3D models that maintain their own tissue structure and function. They
largely overcome the limitations of traditional tumor models and have become a powerful …
largely overcome the limitations of traditional tumor models and have become a powerful …
[HTML][HTML] Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?
A de Pellegars-Malhortie, L Picque Lasorsa, T Mazard… - Pharmaceuticals, 2024 - mdpi.com
Despite significant progress in cancer prevention, screening, and treatment, the still limited
number of therapeutic options is an obstacle towards increasing the cancer cure rate. In …
number of therapeutic options is an obstacle towards increasing the cancer cure rate. In …
Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology
F Mocchegiani, P Vincenzi, G Conte… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Intraductal papillary neoplasms of the bile duct (IPNBs) represent a rare variant of biliary
tumors characterized by a papillary growth within the bile duct lumen. Since their first …
tumors characterized by a papillary growth within the bile duct lumen. Since their first …
Roles of miRNAs in regulating ovarian cancer stemness
C Zhi-**ong - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Ovarian cancer is one of the gynaecology malignancies with the highest mortality rate.
Ovarian cancer stem cell (CSC) is a subpopulation of ovarian cancer cells with increased …
Ovarian cancer stem cell (CSC) is a subpopulation of ovarian cancer cells with increased …
Patient-derived organoids: the beginning of a new era in ovarian cancer disease modeling and drug sensitivity testing
Ovarian cancer (OC) is the leading cause of death from gynecological malignancies.
Despite great advances in treatment strategies, therapeutic resistance and the gap between …
Despite great advances in treatment strategies, therapeutic resistance and the gap between …
[HTML][HTML] O-GlcNAcylation in ovarian tumorigenesis and its therapeutic implications
L **a, J Mei, M Huang, D Bao, Z Wang, Y Chen - Translational Oncology, 2025 - Elsevier
Ovarian cancer is a prevalent malignancy among women, often associated with a poor
prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been …
prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been …