Crosstalk between Wnt/β-catenin signaling pathway and DNA damage response in cancer: a new direction for overcoming therapy resistance

X Zhang, X Yu - Frontiers in Pharmacology, 2023 - frontiersin.org
Wnt signaling plays an important role in regulating the biological behavior of cancers, and
many drugs targeting this signaling have been developed. Recently, a series of research …

Organoids in ovarian cancer: a platform for disease modeling, precision medicine, and drug assessment

H Hu, C Sun, J Chen, Z Li - Journal of Cancer Research and Clinical …, 2024 - Springer
Ovarian cancer (OC) is a major cause of gynecological cancer mortality, necessitating
enhanced research. Organoids, cellular clusters grown in 3D model, have emerged as a …

Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells

J Lee, S Jang, J Im, Y Han, S Kim, HA Jo… - Journal of Ovarian …, 2024 - Springer
Ovarian cancer is a leading cause of death among gynecologic tumors, often detected at
advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors …

Aberrant angiogenic signaling pathways: accomplices in ovarian cancer progression and treatment

W Zhou, T Zeng, J Chen, X Tang, Y Yuan, D Hu… - Cellular …, 2024 - Elsevier
Ovarian cancer is one of the most common malignant tumors in women, and treatment
options are limited. Despite efforts to adjust cancer treatment models and develop new …

Research progress on the application of organoids in gynecological tumors

Y Shen, Y Wang, S Wang, C Li, FJ Han - Frontiers in Pharmacology, 2024 - frontiersin.org
Organoids are in vitro 3D models that maintain their own tissue structure and function. They
largely overcome the limitations of traditional tumor models and have become a powerful …

[HTML][HTML] Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

A de Pellegars-Malhortie, L Picque Lasorsa, T Mazard… - Pharmaceuticals, 2024 - mdpi.com
Despite significant progress in cancer prevention, screening, and treatment, the still limited
number of therapeutic options is an obstacle towards increasing the cancer cure rate. In …

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology

F Mocchegiani, P Vincenzi, G Conte… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Intraductal papillary neoplasms of the bile duct (IPNBs) represent a rare variant of biliary
tumors characterized by a papillary growth within the bile duct lumen. Since their first …

Roles of miRNAs in regulating ovarian cancer stemness

C Zhi-**ong - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Ovarian cancer is one of the gynaecology malignancies with the highest mortality rate.
Ovarian cancer stem cell (CSC) is a subpopulation of ovarian cancer cells with increased …

Patient-derived organoids: the beginning of a new era in ovarian cancer disease modeling and drug sensitivity testing

I Psilopatis, AG Sykaras, G Mandrakis, K Vrettou… - Biomedicines, 2022 - mdpi.com
Ovarian cancer (OC) is the leading cause of death from gynecological malignancies.
Despite great advances in treatment strategies, therapeutic resistance and the gap between …

[HTML][HTML] O-GlcNAcylation in ovarian tumorigenesis and its therapeutic implications

L **a, J Mei, M Huang, D Bao, Z Wang, Y Chen - Translational Oncology, 2025 - Elsevier
Ovarian cancer is a prevalent malignancy among women, often associated with a poor
prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been …