Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

NV Barbosa, CW Nogueira, PA Nogara… - Metallomics, 2017 - academic.oup.com
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

[HTML][HTML] The glutathione system and the related thiol network in Caenorhabditis elegans

GD Ferguson, WJ Bridge - Redox biology, 2019 - Elsevier
Advances in the field of redox biology have contributed to the understanding of the
complexity of the thiol-based system in mediating signal transduction. The redox …

[HTML][HTML] Non-targeted metabolomic profiling of atrazine in Caenorhabditis elegans using UHPLC-QE Orbitrap/MS

J Yin, X Hong, L Ma, R Liu, Y Bu - Ecotoxicology and Environmental Safety, 2020 - Elsevier
The widespread use of the herbicides Atrazine (ATR) has been raised attention due to its
ubiquitous occurrence in the environment. As an endocrine disruptor, ATR causes …

Cytotoxicity of 4-substituted quinoline derivatives: anticancer and antileishmanial potential

CA Costa, RM Lopes, LS Ferraz, GNN Esteves… - Bioorganic & Medicinal …, 2020 - Elsevier
Chemical modifications of quinoline moiety have been recognized as a useful strategy to
development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted …

Neurotoxicity of nonylphenol exposure on Caenorhabditis elegans induced by reactive oxidative species and disturbance synthesis of serotonin

X Cao, X Wang, H Chen, H Li, M Tariq, C Wang… - Environmental …, 2019 - Elsevier
The present study was performed to evaluate the neurobehavioural deficit induced by
nonylphenol (NP), a well-known xenobiotic chemical. The neurotoxic mechanism from …

[HTML][HTML] Organoselenium compounds from purines: synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect

LFB Duarte, RL Oliveira, KC Rodrigues, GT Voss… - Bioorganic & medicinal …, 2017 - Elsevier
We describe here a simple method for the synthesis of 6-arylselanylpurines with antioxidant
and anticholinesterase activities, and memory improvement effect. This class of compounds …

[HTML][HTML] Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

B Yang, Y Lin, Y Huang, YQ Shen, Q Chen - Redox Biology, 2024 - Elsevier
Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …

Evaluation of antioxidant and neuroprotective activities of Cassia fistula (L.) using the Caenorhabditis elegans model

S Thabit, H Handoussa, M Roxo, NS El Sayed… - PeerJ, 2018 - peerj.com
Background Cassia fistula (L.)(Fabaceae) is a medicinal plant from tropical Asia. It is known
for its marked antioxidant activity, which is attributed to its high phenolic content. The present …

Elucidation of the nematicidal mode of action of grammicin on Caenorhabditis elegans

AR Park, K Duraisamy, DD Vo, JC Kim - Pesticide Biochemistry and …, 2022 - Elsevier
Grammicin (Gra) is derived from the endophytic fungus Xylaria grammica EL000614 and
shows nematicidal activity against the devastating root-knot nematode Meloidogyne …

Ultrasound-promoted one-pot synthesis of mono-or bis-substituted organylselanyl pyrroles

TJ Peglow, GP Costa, LFB Duarte… - The Journal of …, 2019 - ACS Publications
A simple method for the direct mono-and bis-organylselenylation of N-substituted pyrroles
through a multicomponent reaction promoted by ultrasonic radiation was described. These …