Organoselenium compounds as mimics of selenoproteins and thiol modifier agents
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …
[HTML][HTML] The glutathione system and the related thiol network in Caenorhabditis elegans
Advances in the field of redox biology have contributed to the understanding of the
complexity of the thiol-based system in mediating signal transduction. The redox …
complexity of the thiol-based system in mediating signal transduction. The redox …
[HTML][HTML] Non-targeted metabolomic profiling of atrazine in Caenorhabditis elegans using UHPLC-QE Orbitrap/MS
J Yin, X Hong, L Ma, R Liu, Y Bu - Ecotoxicology and Environmental Safety, 2020 - Elsevier
The widespread use of the herbicides Atrazine (ATR) has been raised attention due to its
ubiquitous occurrence in the environment. As an endocrine disruptor, ATR causes …
ubiquitous occurrence in the environment. As an endocrine disruptor, ATR causes …
Cytotoxicity of 4-substituted quinoline derivatives: anticancer and antileishmanial potential
CA Costa, RM Lopes, LS Ferraz, GNN Esteves… - Bioorganic & Medicinal …, 2020 - Elsevier
Chemical modifications of quinoline moiety have been recognized as a useful strategy to
development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted …
development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted …
Neurotoxicity of nonylphenol exposure on Caenorhabditis elegans induced by reactive oxidative species and disturbance synthesis of serotonin
X Cao, X Wang, H Chen, H Li, M Tariq, C Wang… - Environmental …, 2019 - Elsevier
The present study was performed to evaluate the neurobehavioural deficit induced by
nonylphenol (NP), a well-known xenobiotic chemical. The neurotoxic mechanism from …
nonylphenol (NP), a well-known xenobiotic chemical. The neurotoxic mechanism from …
[HTML][HTML] Organoselenium compounds from purines: synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect
LFB Duarte, RL Oliveira, KC Rodrigues, GT Voss… - Bioorganic & medicinal …, 2017 - Elsevier
We describe here a simple method for the synthesis of 6-arylselanylpurines with antioxidant
and anticholinesterase activities, and memory improvement effect. This class of compounds …
and anticholinesterase activities, and memory improvement effect. This class of compounds …
[HTML][HTML] Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases
B Yang, Y Lin, Y Huang, YQ Shen, Q Chen - Redox Biology, 2024 - Elsevier
Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …
Evaluation of antioxidant and neuroprotective activities of Cassia fistula (L.) using the Caenorhabditis elegans model
Background Cassia fistula (L.)(Fabaceae) is a medicinal plant from tropical Asia. It is known
for its marked antioxidant activity, which is attributed to its high phenolic content. The present …
for its marked antioxidant activity, which is attributed to its high phenolic content. The present …
Elucidation of the nematicidal mode of action of grammicin on Caenorhabditis elegans
Grammicin (Gra) is derived from the endophytic fungus Xylaria grammica EL000614 and
shows nematicidal activity against the devastating root-knot nematode Meloidogyne …
shows nematicidal activity against the devastating root-knot nematode Meloidogyne …
Ultrasound-promoted one-pot synthesis of mono-or bis-substituted organylselanyl pyrroles
TJ Peglow, GP Costa, LFB Duarte… - The Journal of …, 2019 - ACS Publications
A simple method for the direct mono-and bis-organylselenylation of N-substituted pyrroles
through a multicomponent reaction promoted by ultrasonic radiation was described. These …
through a multicomponent reaction promoted by ultrasonic radiation was described. These …